Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects

Fontana, Pierre; Dupont, Annabelle; Gandrille, Sophie; Bachelot-Loza, Christilla; Reny, Jean-Luc; Aiach, Martine; Gaussem, Pascale

doi:10.1161/01.CIR.0000085073.69189.88

Scientific article

Open access

English

Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects

ContributorsFontana, Pierre; Dupont, Annabelle; Gandrille, Sophie; Bachelot-Loza, Christilla; Reny, Jean-Luc

; Aiach, Martine; Gaussem, Pascale

Published inCirculation, vol. 108, no. 8, p. 989-995

Publication date2003

Abstract

The adenosine diphosphate (ADP) receptor P2Y12 plays a pivotal role in platelet aggregation, as demonstrated by the benefit conferred by its blockade in patients with cardiovascular disease. Some studies have shown interindividual differences in ADP-induced platelet aggregation responses ex vivo, but the mechanisms underlying this variability are unknown.

Keywords

Adenosine Diphosphate/pharmacology
Adolescent
Adult
Alleles
Base Sequence
Blood Platelets/drug effects/metabolism
Cyclic AMP/metabolism
Dose-Response Relationship, Drug
Drug Resistance/genetics
Genetic Testing
Genetic Variation
Haplotypes
Heterozygote
Humans
Integrin beta3/genetics
Male
Membrane Proteins
Molecular Sequence Data
Platelet Aggregation/drug effects/genetics
Polymorphism, Genetic
Receptors, Purinergic P2/genetics
Receptors, Purinergic P2Y12
Reference Values

Affiliation Not a UNIGE publication

Research group

Geneva Platelet Group (13)

Funding

Swiss National Science Foundation - 81LA-63350

Citation (ISO format)

FONTANA, Pierre et al. Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. In: Circulation, 2003, vol. 108, n° 8, p. 989–995. doi: 10.1161/01.CIR.0000085073.69189.88

Article (Accepted version)

Identifiers

PID : unige:136230
DOI : 10.1161/01.CIR.0000085073.69189.88
PMID : 12912815

ISSN of the journal0009-7322

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Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects

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