Doctoral thesis

The role of BTN2A2 in immune regulation of B Cells

ContributorsCadosch, Ilke
DirectorsReith, Walter
Defense date2019-12-17

BTN molecules show the structural and functional similarities to the B7 family of molecules. Btn2a2-/- mice were shown to have increased CD4+ T cell responses and resistance to tumors, stronger autoimmunity. In this thesis, firstly, it was discovered that marginal zone B cells express the highest levels of Btn2a2. Then, it was found that Th1 and Th2 CD4+ T cell responses are stronger in CD19-cre x Btn2a2flfl mice. CD8+ central memory T cells were found to be higher in both CD19-cre x Btn2a2flfl and Btn2a2-/- mice compared to CD19-cre and WT mice. BTN2A2 absence worsened the lupus symptoms in Btn2a2-/-Nba2.Yaa spontaneous disease model. From these data, the roles of BTN2A2 in B cells are elucidated and the most important immune cell types that are affected by the loss of BTN2A2 are concluded.

Citation (ISO format)
CADOSCH, Ilke. The role of BTN2A2 in immune regulation of B Cells. 2019. doi: 10.13097/archive-ouverte/unige:131775
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Creation02/08/2020 11:38:00 AM
First validation02/08/2020 11:38:00 AM
Update time03/15/2023 9:12:19 PM
Status update03/15/2023 9:12:18 PM
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