Thesis (3.6 MB) - 
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Doctoral Thesis
unige:131775 
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The role of BTN2A2 in immune regulation of B Cells |
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| Defense | Thèse de doctorat : Univ. Genève, 2019 - Sc. Vie - Bioméd. 41 - 2019/12/17 | |
| Abstract | BTN molecules show the structural and functional similarities to the B7 family of molecules. Btn2a2-/- mice were shown to have increased CD4+ T cell responses and resistance to tumors, stronger autoimmunity. In this thesis, firstly, it was discovered that marginal zone B cells express the highest levels of Btn2a2. Then, it was found that Th1 and Th2 CD4+ T cell responses are stronger in CD19-cre x Btn2a2flfl mice. CD8+ central memory T cells were found to be higher in both CD19-cre x Btn2a2flfl and Btn2a2-/- mice compared to CD19-cre and WT mice. BTN2A2 absence worsened the lupus symptoms in Btn2a2-/-Nba2.Yaa spontaneous disease model. From these data, the roles of BTN2A2 in B cells are elucidated and the most important immune cell types that are affected by the loss of BTN2A2 are concluded. | |
| Identifiers | URN: urn:nbn:ch:unige-1317756 | |
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| Research group | Groupe Reith Walter (pathologie et immunologie) (282) | |
| Citation (ISO format) | CADOSCH, Ilke. The role of BTN2A2 in immune regulation of B Cells. Université de Genève. Thèse, 2019. doi: 10.13097/archive-ouverte/unige:131775 https://archive-ouverte.unige.ch/unige:131775 |
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