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The role of BTN2A2 in immune regulation of B Cells

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Defense Thèse de doctorat : Univ. Genève, 2019 - Sc. Vie - Bioméd. 41 - 2019/12/17
Abstract BTN molecules show the structural and functional similarities to the B7 family of molecules. Btn2a2-/- mice were shown to have increased CD4+ T cell responses and resistance to tumors, stronger autoimmunity. In this thesis, firstly, it was discovered that marginal zone B cells express the highest levels of Btn2a2. Then, it was found that Th1 and Th2 CD4+ T cell responses are stronger in CD19-cre x Btn2a2flfl mice. CD8+ central memory T cells were found to be higher in both CD19-cre x Btn2a2flfl and Btn2a2-/- mice compared to CD19-cre and WT mice. BTN2A2 absence worsened the lupus symptoms in Btn2a2-/-Nba2.Yaa spontaneous disease model. From these data, the roles of BTN2A2 in B cells are elucidated and the most important immune cell types that are affected by the loss of BTN2A2 are concluded.
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URN: urn:nbn:ch:unige-1317756
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Research group Groupe Reith Walter (pathologie et immunologie) (282)
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CADOSCH, Ilke. The role of BTN2A2 in immune regulation of B Cells. Université de Genève. Thèse, 2019. doi: 10.13097/archive-ouverte/unige:131775 https://archive-ouverte.unige.ch/unige:131775

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Deposited on : 2020-03-04

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