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The long and short of fatty acid synthesis

Published in Cell. 2007, vol. 130, no. 4, p. 587-8
Abstract The multienzyme complex that synthesizes very long chain fatty acids is embedded in the membrane of the endoplasmic reticulum. In this issue, Denic and Weissman (2007) describe the reconstitution of this complex in liposomes and reveal how elongase proteins (Elops) determine the final length of the fatty acyl CoA chain.
Keywords Acetyltransferases/metabolismAlcohol Oxidoreductases/metabolismAnimalsCoenzyme A Ligases/metabolismCytoplasm/metabolismEndoplasmic Reticulum/enzymologyEscherichia coli Proteins/isolation & purification/metabolismFatty Acids, Nonesterified/biosynthesisHumansHydro-Lyases/metabolismLiposomes/chemistryModels, BiologicalOxidoreductases/metabolism
PMID: 17719534
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RIEZMAN, Howard. The long and short of fatty acid synthesis. In: Cell, 2007, vol. 130, n° 4, p. 587-8. https://archive-ouverte.unige.ch/unige:13120

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Deposited on : 2011-01-06

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