Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats

Farias Sanches, Eduardo; Van De Looij, Yohan; Aebi Toulotte, Audrey; Da Silva, Analina Raquel; Romero, Jacqueline; Sizonenko, Stéphane

doi:10.3389/fneur.2018.00480

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Title		Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats
Authors		Farias Sanches, Eduardo Van De Looij, Yohan Aebi Toulotte, Audrey Da Silva, Analina Raquel Romero, Jacqueline Sizonenko, Stéphane
Published in		Frontiers in neurology. 2018, vol. 9, 480
Abstract		Prematurity, through brain injury and altered development is a major cause of neurological impairments and can result in motor, cognitive and behavioral deficits later in life. Presently, there are no well-established effective therapies for preterm brain injury and the search for new strategies is needed. Intra-uterine environment plays a decisive role in brain maturation and interventions using the gestational window have been shown to influence long-term health in the offspring. In this study, we investigated whether pregnancy swimming can prevent the neurochemical metabolic alterations and damage that result from postnatal hypoxic-ischemic brain injury (HI) in very immature rats.
Keywords		Brain — Hypoxia-ischemia — Magnetic resonance imaging — Neuroprotection — Pregnancy swimming — Prematurity
Identifiers		DOI: 10.3389/fneur.2018.00480 PMID: 29988536
Full text		Article (Published version) (1.9 MB) - Free access Other version: https://www.frontiersin.org/articles/10.3389/fneur.2018.00480/full
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group		L'imagerie cérébrale (184)
Citation (ISO format)		FARIAS SANCHES, Eduardo et al. Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats. In: Frontiers in Neurology, 2018, vol. 9, p. 480. doi: 10.3389/fneur.2018.00480 https://archive-ouverte.unige.ch/unige:128448

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Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats