UNIGE document Doctoral Thesis
previous document  unige:12828  next document
add to browser collection
Title

Array-comparative genomic hybridization study in diffuse large B-cell lymphoma

Author
Scandurra, Marta
Directors
Bertoni, Francesco
Defense Thèse de doctorat : Univ. Genève, 2010 - Sc. 4251 - 2010/09/27
Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. DLBCL is a heterogeneous disease and to better characterize the molecular mechanisms and to identify new candidate cancer genes, we performed the genome-wide DNA profiles of 166 DLBCL samples uniformly treated with R-CHOP. We evaluated the impact of recurrent aberrations on the clinical outcome of DLBCL patients and we then performed unsupervised clustering to identify biological subgroups according to the genetic features. Indeed, genomic profiling of samples, identified genetic aberrations and clusters, associated with a distinct outcome in DLBCL patients. We also identified a new gain, occurring at 11q24.3, containing two transcription factors, ETS1 and FLI1. We then provided experimental data indicating a role of the two genes in DLBCL pathogenesis.
Keywords Array-CGHB-cell lymphoma
Identifiers
URN: urn:nbn:ch:unige-128288
Full text
Thesis (7.9 MB) - public document Free access
Structures
Citation
(ISO format)
SCANDURRA, Marta. Array-comparative genomic hybridization study in diffuse large B-cell lymphoma. Université de Genève. Thèse, 2010. https://archive-ouverte.unige.ch/unige:12828

236 hits

646 downloads

Update

Deposited on : 2010-12-07

Export document
Format :
Citation style :