UNIGE document Scientific Article
previous document  unige:126301  next document
add to browser collection
Title

Factors associated with clinical and radiological status on admission in patients with aneurysmal subarachnoid hemorrhage

Authors
Roethlisberger, Michel
Achermann, Rita
Bawarjan, Schatlo
Stienen, Martin N.
Fung, Christian
D’Alonzo, Donato
Maldaner, Nicolai
show hidden authors show all authors [1 - 23]
Collaboration
Published in Neurosurgical Review. 2018, vol. 41, no. 4, p. 1059-1069
Abstract Grading scales yield objective measure of the severity of aneurysmal subarachnoid hemorrhage and serve as to guide treatment decisions and for prognostication. The purpose of this cohort study was to determine what factors govern a patient's disease-specific admission scores in a representative Central European cohort. The Swiss Study of Subarachnoid Hemorrhage includes anonymized data from all tertiary referral centers serving subarachnoid hemorrhage patients in Switzerland. The 2009-2014 dataset was used to evaluate the impact of patient and aneurysm characteristics on the patients' status at admission using descriptive and multivariate regression analysis. The primary/co-primary endpoints were the GCS and the WFNS grade. The secondary endpoints were the Fisher grade, the presence of a thick cisternal or ventricular clot, the presence of a new focal neurological deficit or cranial nerve palsy, and the patient's intubation status. In our cohort of 1787 consecutive patients, increasing patient age by 10 years and low pre-ictal functional status (mRS 3-5) were inversely correlated with "high" GCS score (GCS ≥ 13) (OR 0.91, 95% CI 0.84-0.97 and OR 0.67, 95% CI 0.31-1.46), "low" WFNS grade (grade VI-V) (OR 1.21, 95% CI 1.04-1.20 and OR 1.47, 95% CI 0.66-3.27), and high Fisher grade (grade III-IV) (OR 1.08, 95% CI 1.00-1.17 and OR 1.54, 95% CI 0.55-4.32). Other independent predictors for the patients' clinical and radiological condition at admission were the ruptured aneurysms' location and its size. In sum, chronological age and pre-ictal functional status, as well as the ruptured aneurysm's location and size, determine the patients' clinical and radiological condition at admission to the tertiary referral hospital.
Keywords AgeAneurysmClinical presentationRadiological presentationSubarachnoid hemorrhage
Identifiers
PMID: 29428981
Full text
Article (Published version) (718 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://link.springer.com/10.1007/s10143-018-0952-2
Structures
Research groups Groupe Schaller Karl Lothard (neurochirurgie) (851)
Groupe Pierre Burkhard (neurologie) (154)
Citation
(ISO format)
ZUMOFEN, Daniel Walter et al. Factors associated with clinical and radiological status on admission in patients with aneurysmal subarachnoid hemorrhage. In: Neurosurgical Review, 2018, vol. 41, n° 4, p. 1059-1069. doi: 10.1007/s10143-018-0952-2 https://archive-ouverte.unige.ch/unige:126301

154 hits

0 download

Update

Deposited on : 2019-11-14

Export document
Format :
Citation style :