Factors associated with clinical and radiological status on admission in patients with aneurysmal subarachnoid hemorrhage

Article Article scientifique Article Factors associated with clinical and radiological status on admission in patients with aneurysmal subarachnoid hemorrhage eng 2018 author Zumofen Daniel Walter 506324 author Roethlisberger Michel author Achermann Rita author Bawarjan Schatlo author Stienen Martin N. author Fung Christian author D'Alonzo Donato author Maldaner Nicolai author Ferrari Andrea author Corniola Marco Vincenzo 0000-0003-4447-4585 583144 author Schoeni Daniel author Goldberg Johannes author Valsecchi Daniele author Robertson Thomas 509843 author Maduri Rodolfo author Seule Martin author Burkhardt Jan-Karl author Marbacher Serge author Bijlenga Philippe Alexandre Pierre 104899 author Blackham Kristine A. author Bucher Heiner C. author Mariani Luigi author Guzman Raphael Swiss SOS Study Group 1059-1069 10.1007/s10143-018-0952-2 29428981 0344-5607 http://link.springer.com/10.1007/s10143-018-0952-2 Grading scales yield objective measure of the severity of aneurysmal subarachnoid hemorrhage and serve as to guide treatment decisions and for prognostication. The purpose of this cohort study was to determine what factors govern a patient's disease-specific admission scores in a representative Central European cohort. The Swiss Study of Subarachnoid Hemorrhage includes anonymized data from all tertiary referral centers serving subarachnoid hemorrhage patients in Switzerland. The 2009-2014 dataset was used to evaluate the impact of patient and aneurysm characteristics on the patients' status at admission using descriptive and multivariate regression analysis. The primary/co-primary endpoints were the GCS and the WFNS grade. The secondary endpoints were the Fisher grade, the presence of a thick cisternal or ventricular clot, the presence of a new focal neurological deficit or cranial nerve palsy, and the patient's intubation status. In our cohort of 1787 consecutive patients, increasing patient age by 10 years and low pre-ictal functional status (mRS 3-5) were inversely correlated with "high" GCS score (GCS ≥ 13) (OR 0.91, 95% CI 0.84-0.97 and OR 0.67, 95% CI 0.31-1.46), "low" WFNS grade (grade VI-V) (OR 1.21, 95% CI 1.04-1.20 and OR 1.47, 95% CI 0.66-3.27), and high Fisher grade (grade III-IV) (OR 1.08, 95% CI 1.00-1.17 and OR 1.54, 95% CI 0.55-4.32). Other independent predictors for the patients' clinical and radiological condition at admission were the ruptured aneurysms' location and its size. In sum, chronological age and pre-ictal functional status, as well as the ruptured aneurysm's location and size, determine the patients' clinical and radiological condition at admission to the tertiary referral hospital. Age Aneurysm Clinical presentation Radiological presentation Subarachnoid hemorrhage Dewey 616.8 61 Département des neurosciences cliniques 226 false 124 Groupe Pierre Burkhard (neurologie) 154 513 Groupe Schaller Karl Lothard (neurochirurgie) 851 Neurosurgical Review 41 4 e307da7e-5f5e-47c1-8974-7fd31373c2e0 Article (Published version) Restricted Zumofen2018_Article_FactorsAssociatedWithClinicalA.pdf 735720 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Factors associated with clinical and radiological status on admission in patients with aneurysmal subarachnoid hemorrhage	Neurosurgical Review			2018	362	0

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