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Toxoplasmosis in Transplant Recipients, Europe, 2010-2014

Robert-Gangneux, Florence
Meroni, Valeria
Botterel, Françoise
Brenier-Pinchart, Marie-Pierre
Accoceberry, Isabelle
Akan, Hamdi
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Published in Emerging infectious diseases. 2018, vol. 24, no. 8, p. 1497-1504
Abstract Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.
Keywords EuropeToxoplasmaCerebral toxoplasmosisChemoprophylaxisCotrimoxazoleHematopoietic stem cell transplantParasitesToxoplasma infectionTransplant recipientTransplantation
PMID: 30014843
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Research groups La transplantation d'îlots de Langerhans (623)
Quorom-sensing et gènes de virulence (301)
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ROBERT-GANGNEUX, Florence et al. Toxoplasmosis in Transplant Recipients, Europe, 2010-2014. In: Emerging Infectious Diseases, 2018, vol. 24, n° 8, p. 1497-1504. doi: 10.3201/eid2408.180045 https://archive-ouverte.unige.ch/unige:126292

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Deposited on : 2019-11-14

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