Toxoplasmosis in Transplant Recipients, Europe, 2010-2014

Article Article scientifique Article Toxoplasmosis in Transplant Recipients, Europe, 2010-2014 eng 2018 author Robert-Gangneux Florence author Meroni Valeria author Dupont Damien Olivier 30131 author Botterel Françoise author Garcia Jose-Manuel 865424 author Brenier-Pinchart Marie-Pierre author Accoceberry Isabelle author Akan Hamdi author Abbate Isabella author Boggian Katia author Bruschi Fabrizio author Carratalà Jordi author David Miruna author Drgona Lubos author Djurković-Djaković Olgica author Farinas Maria Carmen author Genco Francesca author Gkrania-Klotsas Effrossyni author Groll Andreas H author Guy Edward author Hirzel Cédric author Khanna Nina author Kurt Özgür author Junie Lia Monica author Lazzarotto Tiziana author Len Oscar author Mueller Nicolas J author Munoz Patricia author Pana Zoi Dorothea author Roilides Emmanuel author Stajner Tijana author Van Delden Christian 24088 author Villena Isabelle author Pelloux Hervé author Manuel Oriol 1497-1504 10.3201/eid2408.180045 30014843 1080-6040 Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management. Europe Toxoplasma Cerebral toxoplasmosis Chemoprophylaxis Cotrimoxazole Hematopoietic stem cell transplant Parasites Toxoplasma infection Transplant recipient Transplantation Dewey 617 57 Département de chirurgie 222 false 357 La transplantation d'îlots de Langerhans 623 235 Perception du Quorum et gènes de virulence 301 Emerging Infectious Diseases 24 8 60dcfdb8-ac60-4542-b68f-f75607700f65 Article (Published version) Public 18-0045.pdf 539943 application/pdf 049d4338-ec1a-422f-bcc2-1f3c43261db1 Appendix Public 18-0045-Techapp-s1.pdf 288122 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Toxoplasmosis in Transplant Recipients, Europe, 2010-2014	Emerging Infectious Diseases			2018	412	242

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Dupont, Damien Olivier