Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

Lian, Shu; Xie, Ruizhi; Ye, Yuying; Xie, Xiaodong; Li, Shuhui; Lu, Yusheng; Li, Bifei; Cheng, Yunlong; Katanaev, Vladimir; Jia, Lee

doi:10.1016/j.ebiom.2019.03.018

Scientific article

English

Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

ContributorsLian, Shu; Xie, Ruizhi; Ye, Yuying; Xie, Xiaodong; Li, Shuhui; Lu, Yusheng; Li, Bifei; Cheng, Yunlong; Katanaev, Vladimir

; Jia, Lee

Published inEBioMedicine, vol. 42, p. 281-295

Publication date2019

Abstract

Treatment multiple tumors by immune therapy can be achieved by mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical "don't find me" signal to the adaptive immune system. Equally CD47 is a critical "don't eat me" signal to the innate immune system and a regulator of the adaptive immune response.

Keywords

Adaptive Immunity
B7-H1 Antigen/metabolism
Biomarkers
CD47 Antigen/metabolism
Cytokines/metabolism
Cytotoxicity
Immunologic
Humans
Immunity
Innate
Immunohistochemistry
Neoplasms/immunology/metabolism/pathology
T-Lymphocytes/immunology/metabolism

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Research groups

Voies de signalisation oncogéniques (998)

Citation (ISO format)

LIAN, Shu et al. Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release. In: EBioMedicine, 2019, vol. 42, p. 281–295. doi: 10.1016/j.ebiom.2019.03.018

Article (Published version)

CC BY-NC-ND

Identifiers

PID : unige:125423
DOI : 10.1016/j.ebiom.2019.03.018
PMID : 30878596

Journal ISSN2352-3964

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Creation31/10/2019 12:13:00

First validation31/10/2019 12:13:00

Update time15/03/2023 18:17:20

Status update15/03/2023 18:17:19

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Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

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