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Scientific article
Open access
English

Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

Published inEBioMedicine, vol. 42, p. 281-295
Publication date2019
Abstract

Treatment multiple tumors by immune therapy can be achieved by mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical "don't find me" signal to the adaptive immune system. Equally CD47 is a critical "don't eat me" signal to the innate immune system and a regulator of the adaptive immune response.

Keywords
  • Adaptive Immunity
  • B7-H1 Antigen/metabolism
  • Biomarkers
  • CD47 Antigen/metabolism
  • Cytokines/metabolism
  • Cytotoxicity
  • Immunologic
  • Humans
  • Immunity
  • Innate
  • Immunohistochemistry
  • Neoplasms/immunology/metabolism/pathology
  • T-Lymphocytes/immunology/metabolism
Citation (ISO format)
LIAN, Shu et al. Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release. In: EBioMedicine, 2019, vol. 42, p. 281–295. doi: 10.1016/j.ebiom.2019.03.018
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Article (Published version)
Identifiers
ISSN of the journal2352-3964
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109downloads

Technical informations

Creation10/31/2019 12:13:00 PM
First validation10/31/2019 12:13:00 PM
Update time03/15/2023 6:17:20 PM
Status update03/15/2023 6:17:19 PM
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