Developing countries have the burden of acute and chronic diseases with the greatest health disparities. There is also a shortfall of more than four million healthcare workers worldwide, and the proportion is higher in less economically viable countries where the lack of proper trained healthcare workers is also compromised by the migration and departure of skilled personnel together with a frail infrastructure and a shortage of resources that cannot provide a proper scenario for an adequate healthcare system that will fulfill the population needs. The need for both technology infrastructure and individuals who have the skills to develop these systems is great, but so are the challenges in developing the needed workforce who are well-trained in informatics. This chapter describes the current informatics education efforts in three regions: Latin America, Sub-Saharan Africa and the Asia-Pacific region. The description of specific healthcare informatics education programs, the educational methods used and the challenges encountered are explored.