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Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules

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Published in Journal of the American Chemical Society. 2019, vol. 141, no. 41, p. 16288-16295
Abstract DNA-based circuitry empowers logic gated operations and amplifications but is restricted to nucleic acid output. Templated reactions enable the translation of nucleic acid cues into diverse small-molecule outputs but are more limited in their amplification. Herein, we demonstrate the coupling of a DNA circuit to templated reactions in order to achieve high levels of amplification in the output of small molecules, in response to nucleic acid input. We demonstrate that the coupling of the DNA circuit to templated reactions allows for the detection of the fM concentration of analyte and can respond with the release of a cytotoxic drug.
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Other version: https://pubs.acs.org/doi/10.1021/jacs.9b05688
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Research group Groupe Winssinger
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KIM, Kitae et al. Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules. In: Journal of the American Chemical Society, 2019, vol. 141, n° 41, p. 16288-16295. doi: 10.1021/jacs.9b05688 https://archive-ouverte.unige.ch/unige:124481

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Deposited on : 2019-10-16

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