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Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules

Published inJournal of the American Chemical Society, vol. 141, no. 41, p. 16288-16295
Publication date2019
Abstract

DNA-based circuitry empowers logic gated operations and amplifications but is restricted to nucleic acid output. Templated reactions enable the translation of nucleic acid cues into diverse small-molecule outputs but are more limited in their amplification. Herein, we demonstrate the coupling of a DNA circuit to templated reactions in order to achieve high levels of amplification in the output of small molecules, in response to nucleic acid input. We demonstrate that the coupling of the DNA circuit to templated reactions allows for the detection of the fM concentration of analyte and can respond with the release of a cytotoxic drug.

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Citation (ISO format)
KIM, Kitae et al. Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules. In: Journal of the American Chemical Society, 2019, vol. 141, n° 41, p. 16288–16295. doi: 10.1021/jacs.9b05688
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ISSN of the journal0002-7863
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Creation10/16/2019 9:45:00 AM
First validation10/16/2019 9:45:00 AM
Update time03/15/2023 6:11:38 PM
Status update03/15/2023 6:11:37 PM
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