Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
ContributorsReckel, Sina; Gehin, Charlotte; Tardivon, Delphine; Georgeon, Sandrine; Kükenshöner, Tim; Löhr, Frank; Koide, Akiko; Buchner, Lena; Panjkovich, Alejandro; Reynaud, Aline; Pinho, Sara; Gerig, Barbara; Svergun, Dmitri; Pojer, Florence; Güntert, Peter; Dötsch, Volker; Koide, Shohei; Gavin Perrin, Anne-Claude; Hantschel, Oliver
Published inNature Communications, vol. 8, no. 1, 2101
Publication date2017
Abstract
Keywords
- Carcinogenesis
- Crystallography
- X-Ray
- Fusion Proteins
- Bcr-abl/chemistry/genetics/metabolism
- Humans
- Leukemia/genetics/metabolism
- Magnetic Resonance Spectroscopy
- Models
- Molecular
- Pleckstrin Homology Domains
- Protein Domains
- Scattering
- Small Angle
- Signal Transduction
- X-Ray Diffraction
Affiliation entities Not a UNIGE publication
Research groups
Funding
- Swiss National Science Foundation - Comparative analysis of signaling by the p210 and p185 isoforms of the human Bcr-Abl oncoprotein [140913]
- Autre - ERC-2016-CoG 682311-ONCOINTRABODY
Citation (ISO format)
RECKEL, Sina et al. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. In: Nature Communications, 2017, vol. 8, n° 1, p. 2101. doi: 10.1038/s41467-017-02313-6
Main files (1)
Article (Published version)
Identifiers
- PID : unige:124440
- DOI : 10.1038/s41467-017-02313-6
- PMID : 29235475
Additional URL for this publicationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727386/
Journal ISSN2041-1723