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The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

Contributors

Chiapparino, Antonella; Maeda, Kenji; Turei, Denes; Saez-Rodriguez, Julio; Gavin Perrin, Anne-Claude

Published in

Progress in Lipid Research, vol. 61, p. 30-39

Publication date

2016

Abstract

Within the eukaryotic cell, more than 1000 species of lipids define a series of membranes essential for cell function. Tightly controlled systems of lipid transport underlie the proper spatiotemporal distribution of membrane lipids, the coordination of spatially separated lipid metabolic pathways, and lipid signaling mediated by soluble proteins that may be localized some distance away from membranes. Alongside the well-established vesicular transport of lipids, non-vesicular transport mediated by a group of proteins referred to as lipid-transfer proteins (LTPs) is emerging as a key mechanism of lipid transport in a broad range of biological processes. More than a hundred LTPs exist in humans and these can be divided into at least ten protein families. LTPs are widely distributed in tissues, organelles and membrane contact sites (MCSs), as well as in the extracellular space. They all possess a soluble and globular domain that encapsulates a lipid monomer and they specifically bind and transport a wide range of lipids. Here, we present the most recent discoveries in the functions and physiological roles of LTPs, which have expanded the playground of lipids into the aqueous spaces of cells.

Keywords

  • Biological membranes
  • Biomolecular networks
  • Lipid-binding domains
  • Lipid-transfer proteins
  • Membrane contact sites
  • Metabolism
  • Non-vesicular lipid trafficking
  • Organelles
  • Signaling lipid
  • Systems biology
  • Transport

UNIGE affiliation entities

Not a UNIGE publication

UNIGE research groups

Citation (ISO format)

CHIAPPARINO, Antonella et al. The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling. In: Progress in Lipid Research, 2016, vol. 61, p. 30–39. doi: 10.1016/j.plipres.2015.10.004

Main files (1)

Article (Published version)
CC BY-NC-ND

Identifiers

Journal ISSN

0163-7827
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575downloads

Technical informations

Creation

14/10/2019 15:16:00

First validation

14/10/2019 15:16:00

Update

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