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Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

Published inCurrent Opinion in Chemical Biology, vol. 52, p. 112-124
Publication date2019
Abstract

Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.

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Citation (ISO format)
SAARBACH, Jacques, SABALE, Pramod Madhavrao, WINSSINGER, Nicolas. Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics. In: Current Opinion in Chemical Biology, 2019, vol. 52, p. 112–124. doi: 10.1016/j.cbpa.2019.06.006
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ISSN of the journal1367-5931
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Technical informations

Creation09/25/2019 3:19:00 PM
First validation09/25/2019 3:19:00 PM
Update time03/15/2023 6:04:35 PM
Status update03/15/2023 6:04:35 PM
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