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Title

Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model

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Published in Journal of Cellular and Molecular Medicine. 2019, vol. 23, no. 8, p. 5808-5812
Abstract Endometriosis is an oestrogen-dependent, inflammation-driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up-regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long-term clinical use. An endometriosis-targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens produced by CAM female embryo blunted this effect. Xenografted human endometriosis CAM is a new efficient model for the screening of new drugs targeting endometriosis tissue.
Keywords AnastrozoleChick embryo chorioallantoic membraneEndometriosis
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PMID: 31199588
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Article (Published version) (669 Kb) - public document Free access
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Research groups Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
Prévention du cancer du col utérin (933)
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PLUCHINO, Nicola et al. Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model. In: Journal of Cellular and Molecular Medicine, 2019, vol. 23, n° 8, p. 5808-5812. doi: 10.1111/jcmm.14372 https://archive-ouverte.unige.ch/unige:123524

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Deposited on : 2019-09-24

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