Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model

Article Article scientifique Article Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model eng 2019 author Pluchino Nicola 0000-0002-7475-9082 861020 author Poppi Giorgia 876239 author Yart Lucile Adeline 862030 author Marci Roberto 847493 author Wenger Jean-Marie 66689 author Tille Jean-Christophe 87627 author Cohen Marie-Benoîte 0000-0003-4621-5464 135615 5808-5812 10.1111/jcmm.14372 31199588 1582-1838 Endometriosis is an oestrogen-dependent, inflammation-driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up-regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long-term clinical use. An endometriosis-targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens produced by CAM female embryo blunted this effect. Xenografted human endometriosis CAM is a new efficient model for the screening of new drugs targeting endometriosis tissue. Anastrozole Chick embryo chorioallantoic membrane Endometriosis Dewey 616.07 Dewey 618 137 Département de pathologie et immunologie 21F 58 Département de pédiatrie, gynécologie et obstétrique 223 false 584 Laboratoire de biologie des tumeurs gynécologiques et du développement 927 590 Prévention du cancer du col utérin 933 Journal of Cellular and Molecular Medicine 23 8 64a94f79-7be6-47c3-a547-9cee71b1d014 Article (Published version) Public Article-6.pdf 684878 application/pdf CC BY openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model	Journal of Cellular and Molecular Medicine			2019	508	320

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Poppi, Giorgia