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Title

Diagnostic accuracy of different soluble fms-like tyrosine kinase 1 and placental growth factor cut-off values in the assessment of preterm and term preeclampsia: a gestational age matched case-control study

Authors
Huhn, Evelyn A
Kreienbühl, Andrea
Hoffmann, Ina
Schoetzau, Andreas
Hund, Martin
Hoesli, Irene
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Published in Frontiers in Medicine. 2018, vol. 5, p. 325
Abstract Introduction: The objective was to investigate the diagnostic accuracy of different thresholds of the soluble vascular endothelial growth factor receptor-1 (sFlt-1) and the placental growth factor (PlGF) in preterm (≤37 weeks) and term (>37 weeks) preeclampsia (PE). Materials and Methods: A nested case-control study was performed from a high-risk Swiss cohort. Only blood samples on the day of PE diagnosis were included. The primary outcome was to verify the diagnosis using the recently proposed cut-off values for PE (sFlt-1:PlGF ratio of ≥85 in ≤ 34 weeks or ≥110 in >34 weeks), and the gestational age dependent centiles. Results: Thirty-four women with preterm PE were matched with 64 controls and 25 women with term PE with 45 controls. The test performance of the sFlt-1:PlGF ratio in preterm PE was very good (AUROCC of 0.95). The sFlt-1:PlGF ratio could adequately predict adverse fetal or neonatal outcome. In term PE, sFlt-1 alone showed a slightly better diagnostic accuracy with an AUROCC of 0.84. Almost all women with a sFlt-1:PlGF ratio above threshold delivered during the following week. Discussion: In pregnant women with high risk of developing PE, the sFlt-1:PlGF ratio and sFlt-1 levels help clinicians to confirm the diagnosis of imminent preterm PE and can additionally be used to rule out PE at term.
Keywords PlGFBiomarkerDiagnosisHypertension in pregnancyPreeclampsiaSFlt-1SFlt-1:PlGF ratio
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PMID: 30560128
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Research group Martinez De Tejada Begona (272)
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HUHN, Evelyn A et al. Diagnostic accuracy of different soluble fms-like tyrosine kinase 1 and placental growth factor cut-off values in the assessment of preterm and term preeclampsia: a gestational age matched case-control study. In: Frontiers in Medicine, 2018, vol. 5, p. 325. doi: 10.3389/fmed.2018.00325 https://archive-ouverte.unige.ch/unige:123499

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Deposited on : 2019-09-23

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