Diagnostic accuracy of different soluble fms-like tyrosine kinase 1 and placental growth factor cut-off values in the assessment of preterm and term preeclampsia: a gestational age matched case-control study

Article Article scientifique Article Diagnostic accuracy of different soluble fms-like tyrosine kinase 1 and placental growth factor cut-off values in the assessment of preterm and term preeclampsia: a gestational age matched case-control study eng 2018 author Huhn Evelyn A author Kreienbühl Andrea author Hoffmann Ina author Schoetzau Andreas author Lange Soeren 716342 author Martinez De Tejada Weber Begona 590919 author Hund Martin author Hoesli Irene author Lapaire Olav 325 10.3389/fmed.2018.00325 30560128 2296-858X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284367/ Introduction: The objective was to investigate the diagnostic accuracy of different thresholds of the soluble vascular endothelial growth factor receptor-1 (sFlt-1) and the placental growth factor (PlGF) in preterm (≤37 weeks) and term (>37 weeks) preeclampsia (PE). Materials and Methods: A nested case-control study was performed from a high-risk Swiss cohort. Only blood samples on the day of PE diagnosis were included. The primary outcome was to verify the diagnosis using the recently proposed cut-off values for PE (sFlt-1:PlGF ratio of ≥85 in ≤ 34 weeks or ≥110 in >34 weeks), and the gestational age dependent centiles. Results: Thirty-four women with preterm PE were matched with 64 controls and 25 women with term PE with 45 controls. The test performance of the sFlt-1:PlGF ratio in preterm PE was very good (AUROCC of 0.95). The sFlt-1:PlGF ratio could adequately predict adverse fetal or neonatal outcome. In term PE, sFlt-1 alone showed a slightly better diagnostic accuracy with an AUROCC of 0.84. Almost all women with a sFlt-1:PlGF ratio above threshold delivered during the following week. Discussion: In pregnant women with high risk of developing PE, the sFlt-1:PlGF ratio and sFlt-1 levels help clinicians to confirm the diagnosis of imminent preterm PE and can additionally be used to rule out PE at term. PlGF Biomarker Diagnosis Hypertension in pregnancy Preeclampsia SFlt-1 SFlt-1:PlGF ratio Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 213 Martinez De Tejada Begona 272 Frontiers in Medicine 5 e0143767-53d5-4996-8c4f-f7e745d80d0f Article (Published version) Public fmed-05-00325.pdf 1788450 application/pdf CC BY openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Diagnostic accuracy of different soluble fms-like tyrosine kinase 1 and placental growth factor cut-off values in the assessment of preterm and term preeclampsia: a gestational age matched case-control study	Frontiers in Medicine			2018	353	263

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