Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies
ContributorsNicoli, Raul; Bartolini, Manuela; Rudaz, Serge; Andrisano, Vincenza; Veuthey, Jean-Luc
Published inJournal of chromatography, vol. 1206, no. 1, p. 2-10
Publication date2008
Abstract
Keywords
- Avidin
- Bioreactors
- Biotinylation
- Chromatography, Liquid/instrumentation/methods
- Cytochrome P-450 CYP2D6/antagonists & inhibitors/metabolism
- Cytochrome P-450 CYP3A/antagonists & inhibitors/metabolism
- Drug Evaluation, Preclinical/methods
- Enzyme Inhibitors/pharmacology
- Enzyme Stability
- Enzymes, Immobilized/metabolism
- Humans
- Kinetics
- Microsomes, Liver/chemistry
- Recombinant Proteins/metabolism
- Spectrometry, Mass, Electrospray Ionization/instrumentation/methods
Affiliation entities
Citation (ISO format)
NICOLI, Raul et al. Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies. In: Journal of chromatography, 2008, vol. 1206, n° 1, p. 2–10. doi: 10.1016/j.chroma.2008.05.080
Main files (1)
Article (Accepted version)
Identifiers
- PID : unige:1233
- DOI : 10.1016/j.chroma.2008.05.080
- PMID : 18556005
ISSN of the journal0021-9673