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CD8+ T cells induce cachexia during chronic viral infection |
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Published in | Nature immunology. 2019, vol. 20, no. 6, p. 701-710 | |
Abstract | Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC. Cytokines linked to cancer-associated cachexia did not contribute to IAC. Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming. Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC. | |
Keywords | Adipose Tissue/diagnostic imaging/immunology/metabolism/virology — Animals — CD8-Positive T-Lymphocytes/immunology/metabolism — Cachexia/diagnostic imaging/etiology/metabolism/pathology — Chronic Disease — Cytokines/blood/metabolism — Female — Interferon Type I/metabolism — Lipid Metabolism — Lipolysis — Lymphocyte Activation/immunology — Lymphocytic choriomeningitis virus — Magnetic Resonance Imaging/methods — Male — Mice — Signal Transduction — Virus Diseases/complications/immunology/virology | |
Identifiers | PMID: 31110314 | |
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Research group | La Sclérose en plaques (908) | |
Projects | European Commission: CMIL European Commission: LIPOCHEX | |
Citation (ISO format) | BAAZIM, Hatoon et al. CD8+ T cells induce cachexia during chronic viral infection. In: Nature Immunology, 2019, vol. 20, n° 6, p. 701-710. doi: 10.1038/s41590-019-0397-y https://archive-ouverte.unige.ch/unige:122877 |