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CD8+ T cells induce cachexia during chronic viral infection

Baazim, Hatoon
Schweiger, Martina
Moschinger, Michael
Xu, Haifeng
Scherer, Thomas
Popa, Alexandra
Gallage, Suchira
Ali, Adnan
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Published in Nature immunology. 2019, vol. 20, no. 6, p. 701-710
Abstract Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC. Cytokines linked to cancer-associated cachexia did not contribute to IAC. Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming. Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC.
Keywords Adipose Tissue/diagnostic imaging/immunology/metabolism/virologyAnimalsCD8-Positive T-Lymphocytes/immunology/metabolismCachexia/diagnostic imaging/etiology/metabolism/pathologyChronic DiseaseCytokines/blood/metabolismFemaleInterferon Type I/metabolismLipid MetabolismLipolysisLymphocyte Activation/immunologyLymphocytic choriomeningitis virusMagnetic Resonance Imaging/methodsMaleMiceSignal TransductionVirus Diseases/complications/immunology/virology
PMID: 31110314
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Research group La Sclérose en plaques (908)
European Commission: CMIL
European Commission: LIPOCHEX
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BAAZIM, Hatoon et al. CD8+ T cells induce cachexia during chronic viral infection. In: Nature Immunology, 2019, vol. 20, n° 6, p. 701-710. doi: 10.1038/s41590-019-0397-y https://archive-ouverte.unige.ch/unige:122877

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Deposited on : 2019-09-09

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