Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles

Guillarme, Davy; Schelling, Cédric; Rudaz, Serge; Veuthey, Jean-Luc

Scientific article

English

Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles

ContributorsGuillarme, Davy; Schelling, Cédric; Rudaz, Serge; Veuthey, Jean-Luc

Published inLC GC Europe, vol. 21, no. 10, p. 488-501

Publication date2008

Abstract

Very short columns filled with 1.9 μm particles were evaluated for the ultra-fast analysis of pharmaceutical formulations. Local anaesthetic, mydriatic and anti-hypertensive agents were chosen as analytes and a method was developed and validated for each of these substances, according to ICH guidelines. Excellent quantitative performance was obtained using an optimized Chromatographie system that reduces the importance of extra-column effects and cuts the analysis time to less than 15 s.

Affiliation

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

GUILLARME, Davy et al. Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles. In: LC GC Europe, 2008, vol. 21, n° 10, p. 488–501.

Article (Accepted version)

Identifiers

PID : unige:1222

ISSN of the journal1471-6577

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Creation2009/03/24 16:36:00

First validation2009/03/24 16:36:00

Update time2023/03/14 15:03:38

Status update2023/03/14 15:03:38

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Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles

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