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Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles

Published in LCGC Europe. 2008, vol. 21, no. 10, p. 488-501
Abstract Very short columns filled with 1.9 μm particles were evaluated for the ultra-fast analysis of pharmaceutical formulations. Local anaesthetic, mydriatic and anti-hypertensive agents were chosen as analytes and a method was developed and validated for each of these substances, according to ICH guidelines. Excellent quantitative performance was obtained using an optimized Chromatographie system that reduces the importance of extra-column effects and cuts the analysis time to less than 15 s.
Stable URL https://archive-ouverte.unige.ch/unige:1222
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Deposited on : 2009-03-24

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