Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles

Guillarme, Davy; Schelling, Cédric; Rudaz, Serge; Veuthey, Jean-Luc

Scientific article

English

Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles

Contributors

Guillarme, Davy; Schelling, Cédric; Rudaz, Serge

; Veuthey, Jean-Luc

Published in

LC GC Europe, vol. 21, no. 10, p. 488-501

Publication date

2008

Abstract

Very short columns filled with 1.9 μm particles were evaluated for the ultra-fast analysis of pharmaceutical formulations. Local anaesthetic, mydriatic and anti-hypertensive agents were chosen as analytes and a method was developed and validated for each of these substances, according to ICH guidelines. Excellent quantitative performance was obtained using an optimized Chromatographie system that reduces the importance of extra-column effects and cuts the analysis time to less than 15 s.

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

GUILLARME, Davy et al. Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles. In: LC GC Europe, 2008, vol. 21, n° 10, p. 488–501.

Article (Accepted version)

Identifiers

PID : unige:1222

Journal ISSN

1471-6577

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Creation

24/03/2009 16:36:00

First validation

24/03/2009 16:36:00

Update

14/03/2023 15:03:38

Status update

14/03/2023 15:03:38

Last indexation

18/03/2025 09:17:04

Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 μm Particles

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation