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Time-of-day-dependent trafficking and function of leukocyte subsets

Pick, Robert
He, Wenyan
Chen, Chien-Sin
Published in Trends in Immunology. 2019, vol. 40, no. 6, p. 524-537
Abstract The number of leukocytes circulating in blood in mammals is under circadian control (i.e., ∼24h). We summarize here latest findings on the mechanisms governing leukocyte migration from the blood into various organs, focusing on the distinct leukocyte subtype- and tissue-specific molecules involved. We highlight the oscillatory expression patterns of adhesion molecules, chemokines, and their receptors that are expressed on endothelial cells and leukocytes, and which are crucial regulators of rhythmic leukocyte recruitment. We also discuss the relevance of clock genes for leukocyte function and migration. Finally, we compare immune cell rhythms under steady-state conditions as well as during inflammation and disease, and we postulate how these findings provide potential new avenues for therapeutic intervention.
PMID: 31109762
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Article (Published version) (2.2 MB) - public document Free access
Research group L'influence du rôle du cycle circadien sur l'immunité (995)
Project FNS: 310030_182417/1
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PICK, Robert et al. Time-of-day-dependent trafficking and function of leukocyte subsets. In: Trends in Immunology, 2019, vol. 40, n° 6, p. 524-537. https://archive-ouverte.unige.ch/unige:121654

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Deposited on : 2019-08-16

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