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Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues |
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Published in | Immunity. 2018, vol. 49, no. 6, p. 1175-1190.e7 | |
Abstract | The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations in pro-migratory factors that were distinct for specific vascular beds and individual leukocyte subsets. This rhythmic molecular signature governed time-of-day-dependent homing behavior of leukocyte subsets to specific organs. Ablation of BMAL1, a transcription factor central to circadian clock function, in endothelial cells or leukocyte subsets demonstrated that rhythmic recruitment is dependent on both microenvironmental and cell-autonomous oscillations. These oscillatory patterns defined leukocyte trafficking in both homeostasis and inflammation and determined detectable tumor burden in blood cancer models. Rhythms in the expression of pro-migratory factors and migration capacities were preserved in human primary leukocytes. The definition of spatial and temporal expression profiles of pro-migratory factors guiding leukocyte migration patterns to organs provides a resource for the further study of the impact of circadian rhythms in immunity. | |
Keywords | Adult — Animals — Cell Adhesion Molecules/genetics/immunology/metabolism — Cell Movement/genetics/immunology — Circadian Rhythm/immunology — Endothelial Cells/immunology/metabolism — Female — Gene Expression Profiling — Gene Expression Regulation/immunology — Homeostasis/genetics/immunology — Humans — Leukocytes/cytology/immunology/metabolism — Male — Mice — Inbred C57BL — Knockout — Transgenic — Middle Aged — Organ Specificity/genetics/immunology — Transcription Factors/genetics/immunology/metabolism | |
Identifiers | PMID: 30527911 | |
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Research group | L'influence du rôle du cycle circadien sur l'immunité (995) | |
Citation (ISO format) | HE, Wenyan et al. Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues. In: Immunity, 2018, vol. 49, n° 6, p. 1175-1190.e7. doi: 10.1016/j.immuni.2018.10.007 https://archive-ouverte.unige.ch/unige:121653 |