Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues

He, Wenyan; Holtkamp, Stephan; Hergenhan, Sophia Martina; Kraus, Kerstin; de Juan, Alba; Weber, Jasmin; Bradfield, Paul; Grenier, Julien Martin Pierre; Pelletier, Jeoffrey; Druzd, David; Chen, Chien-Sin; Ince, Louise Madeleine; Bierschenk, Susanne; Pick, Robert; Sperandio, Markus; Aurrand-Lions, Michel; Scheiermann, Christoph

doi:10.1016/j.immuni.2018.10.007

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Title		Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues
Authors		He, Wenyan Holtkamp, Stephan Hergenhan, Sophia Martina Kraus, Kerstin de Juan, Alba Weber, Jasmin Bradfield, Paul Grenier, Julien Martin Pierre Pelletier, Jeoffrey Druzd, David Chen, Chien-Sin Ince, Louise Madeleine Bierschenk, Susanne Pick, Robert Sperandio, Markus Aurrand-Lions, Michel Scheiermann, Christoph show all authors [1 - 17]
Published in		Immunity. 2018, vol. 49, no. 6, p. 1175-1190.e7
Abstract		The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations in pro-migratory factors that were distinct for specific vascular beds and individual leukocyte subsets. This rhythmic molecular signature governed time-of-day-dependent homing behavior of leukocyte subsets to specific organs. Ablation of BMAL1, a transcription factor central to circadian clock function, in endothelial cells or leukocyte subsets demonstrated that rhythmic recruitment is dependent on both microenvironmental and cell-autonomous oscillations. These oscillatory patterns defined leukocyte trafficking in both homeostasis and inflammation and determined detectable tumor burden in blood cancer models. Rhythms in the expression of pro-migratory factors and migration capacities were preserved in human primary leukocytes. The definition of spatial and temporal expression profiles of pro-migratory factors guiding leukocyte migration patterns to organs provides a resource for the further study of the impact of circadian rhythms in immunity.
Keywords		Adult — Animals — Cell Adhesion Molecules/genetics/immunology/metabolism — Cell Movement/genetics/immunology — Circadian Rhythm/immunology — Endothelial Cells/immunology/metabolism — Female — Gene Expression Profiling — Gene Expression Regulation/immunology — Homeostasis/genetics/immunology — Humans — Leukocytes/cytology/immunology/metabolism — Male — Mice — Inbred C57BL — Mice — Knockout — Mice — Transgenic — Middle Aged — Organ Specificity/genetics/immunology — Transcription Factors/genetics/immunology/metabolism
Identifiers		DOI: 10.1016/j.immuni.2018.10.007 PMID: 30527911
Full text		Article (Published version) (3.8 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		L'influence du rôle du cycle circadien sur l'immunité (995)
Citation (ISO format)		HE, Wenyan et al. Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues. In: Immunity, 2018, vol. 49, n° 6, p. 1175-1190.e7. https://archive-ouverte.unige.ch/unige:121653