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Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues

He, Wenyan
Holtkamp, Stephan
Hergenhan, Sophia Martina
Kraus, Kerstin
de Juan, Alba
Weber, Jasmin
Bradfield, Paul
Grenier, Julien Martin Pierre
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Published in Immunity. 2018, vol. 49, no. 6, p. 1175-1190.e7
Abstract The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations in pro-migratory factors that were distinct for specific vascular beds and individual leukocyte subsets. This rhythmic molecular signature governed time-of-day-dependent homing behavior of leukocyte subsets to specific organs. Ablation of BMAL1, a transcription factor central to circadian clock function, in endothelial cells or leukocyte subsets demonstrated that rhythmic recruitment is dependent on both microenvironmental and cell-autonomous oscillations. These oscillatory patterns defined leukocyte trafficking in both homeostasis and inflammation and determined detectable tumor burden in blood cancer models. Rhythms in the expression of pro-migratory factors and migration capacities were preserved in human primary leukocytes. The definition of spatial and temporal expression profiles of pro-migratory factors guiding leukocyte migration patterns to organs provides a resource for the further study of the impact of circadian rhythms in immunity.
Keywords AdultAnimalsCell Adhesion Molecules/genetics/immunology/metabolismCell Movement/genetics/immunologyCircadian Rhythm/immunologyEndothelial Cells/immunology/metabolismFemaleGene Expression ProfilingGene Expression Regulation/immunologyHomeostasis/genetics/immunologyHumansLeukocytes/cytology/immunology/metabolismMaleMiceInbred C57BLKnockoutTransgenicMiddle AgedOrgan Specificity/genetics/immunologyTranscription Factors/genetics/immunology/metabolism
PMID: 30527911
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Research group L'influence du rôle du cycle circadien sur l'immunité (995)
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HE, Wenyan et al. Circadian expression of migratory factors establishes lineage-specific signatures that guide the homing of leukocyte subsets to tissues. In: Immunity, 2018, vol. 49, n° 6, p. 1175-1190.e7. doi: 10.1016/j.immuni.2018.10.007 https://archive-ouverte.unige.ch/unige:121653

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Deposited on : 2019-08-16

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