The Paris Agreement 2015 is a historic initiative taken by the global community to fight against climate change and steer the world towards clean energy transition. The industry sector which accounts for almost one-third of the global final energy demand offers great potential for energy efficiency improvement. Energy efficiency (EE) is also a major pillar of the Swiss Energy Strategy 2050. Although several steps to incentivize EE improvement in industry have been taken in Switzerland, the size of the EE gap that currently exists in its high-value manufacturing sector is largely unknown. Since industrial technologies are advancing rapidly, it is important to evaluate the current diffusion of conventional measures and the potential wide-scale application of emerging technologies in the sector. This thesis employs bottom-up methods to assess the techno-economic final energy saving potentials in industry in the short-to-medium term at the level of individual sectors and for cross-cutting technologies.