en
Scientific article
Open access
English

Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

Published inCellular and molecular life sciences, vol. 65, no. 18, p. 2913-2923
Collection
  • Open Access - Licence nationale Springer
Publication date2008
Abstract

Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.

Keywords
  • Animals
  • Excitatory Postsynaptic Potentials/physiology
  • Humans
  • Long-Term Synaptic Depression/physiology
  • Neuronal Plasticity/physiology
  • Protein Isoforms/metabolism
  • Receptors, Metabotropic Glutamate/metabolism
  • Synapses/physiology
  • Synaptic Transmission/physiology
Citation (ISO format)
BELLONE, Camilla, LUESCHER, Christian, MAMELI, Manuel. Mechanisms of synaptic depression triggered by metabotropic glutamate receptors. In: Cellular and molecular life sciences, 2008, vol. 65, n° 18, p. 2913–2923. doi: 10.1007/s00018-008-8263-3
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1420-682X
560views
331downloads

Technical informations

Creation03/19/2009 5:20:00 PM
First validation03/19/2009 5:20:00 PM
Update time03/14/2023 3:03:33 PM
Status update03/14/2023 3:03:33 PM
Last indexation01/15/2024 6:18:55 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack