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Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

Published in Cellular and Molecular Life Sciences. 2008, vol. 65, no. 18, p. 2913-2923
Abstract Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
Keywords AnimalsExcitatory Postsynaptic Potentials/physiologyHumansLong-Term Synaptic Depression/physiologyNeuronal Plasticity/physiologyProtein Isoforms/metabolismReceptors, Metabotropic Glutamate/metabolismSynapses/physiologySynaptic Transmission/physiology
Stable URL https://archive-ouverte.unige.ch/unige:1202
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PMID: 18712277
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)

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Deposited on : 2009-03-20

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