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Scientific article
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English

Safety issues of pharmacological acute pain treatment in children

Published inClinical Pharmacology and Therapeutics, vol. 105, no. 5, p. 1130-1138
Publication date2019
Abstract

Acute nociceptive pain management in children is a major public health concern. Effective and safe pain treatment is essential, but safety data cannot be simply extrapolated from adults to children due to pharmacokinetic and pharmacodynamic specificities. In addition, the frequent absence of child-specific data, the difficulty to assess drug tolerability, and the infants' inability to communicate properly and voluntarily report adverse drug reactions make children more vulnerable to safety issues. Awareness of the possible toxicity of analgesics is important but should not lead to suboptimal dosing and underuse of analgesia. A better assessment and individualization of treatment should allow effective prescribing of analgesics in more secure conditions. This article aims to review the safety of acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids in children and the precautions that should be taken.

Citation (ISO format)
RODIEUX, Frédérique et al. Safety issues of pharmacological acute pain treatment in children. In: Clinical Pharmacology and Therapeutics, 2019, vol. 105, n° 5, p. 1130–1138. doi: 10.1002/cpt.1358
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ISSN of the journal0009-9236
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Creation05/24/2019 4:13:00 PM
First validation05/24/2019 4:13:00 PM
Update time03/15/2023 5:42:36 PM
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