Scientific article

Indole monoterpenes with antichemotactic activity from Psychotria myriantha: Chemotaxonomic significance

Published inNatural product communications, vol. 1, p. 1101-1106
Publication date2006

The alkaloid extract of the aerial parts of Psychotria myriantha (Rubiaceae) displayed antichemotactic activity on polymorphonuclear leukocytes (PMN) assessed by the Boyden chamber assay. On analysis of the crude extract by LC/APCI/MS and LC/UV/DAD, two major constituents could be detected. In order to rapidly identify the active compounds, a microfractionation was conducted during LC/UV/DAD analysis. By this means, both the collected compounds could be assayed separately in the Boyden chamber and were shown to inhibit PMN chemotaxis. Their isolation was performed by semi-preparative HPLC and their structures elucidated by classical spectroscopic methods, including UV, NMR, MS and HRMS. Both compounds showed characteristics of monoterpene indole glucoside alkaloids; one of them was identified as strictosidinic acid and the other was a new natural product, myrianthosine. The antichemotactic activity of the compounds may be related to an antiacute inflammation activity.

  • Psychotria
  • myriantha
  • rubiaceae
  • antichemotactic
  • activity
  • glucoside
  • indole
  • monoterpene
  • alkaloids
  • myrianthosine
  • strictosidinic
  • acid
  • oleoides
  • plants
Citation (ISO format)
SIMOES AVELLO, Claudia et al. Indole monoterpenes with antichemotactic activity from Psychotria myriantha: Chemotaxonomic significance. In: Natural product communications, 2006, vol. 1, p. 1101–1106.
  • PID : unige:11846
ISSN of the journal1555-9475

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