Indole monoterpenes with antichemotactic activity from Psychotria myriantha: Chemotaxonomic significance

Article Article scientifique Article Indole monoterpenes with antichemotactic activity from Psychotria myriantha: Chemotaxonomic significance eng 2006 author Simoes Avello Claudia 630402 author Farias Facundo Nanouk 659834 author Marston Andrew author Queiroz Emerson F. author Chaves C.G. author Henriques A.T. author Hostettmann Kurt 135647 1101-1106 1555-9475 The alkaloid extract of the aerial parts of Psychotria myriantha (Rubiaceae) displayed antichemotactic activity on polymorphonuclear leukocytes (PMN) assessed by the Boyden chamber assay. On analysis of the crude extract by LC/APCI/MS and LC/UV/DAD, two major constituents could be detected. In order to rapidly identify the active compounds, a microfractionation was conducted during LC/UV/DAD analysis. By this means, both the collected compounds could be assayed separately in the Boyden chamber and were shown to inhibit PMN chemotaxis. Their isolation was performed by semi-preparative HPLC and their structures elucidated by classical spectroscopic methods, including UV, NMR, MS and HRMS. Both compounds showed characteristics of monoterpene indole glucoside alkaloids; one of them was identified as strictosidinic acid and the other was a new natural product, myrianthosine. The antichemotactic activity of the compounds may be related to an antiacute inflammation activity. Psychotria myriantha rubiaceae antichemotactic activity glucoside indole monoterpene alkaloids myrianthosine strictosidinic acid oleoides plants Dewey 615 31 Section des sciences pharmaceutiques 17 false Natural product communications 1 Faculté des sciences / Section des sciences pharmaceutiques

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Indole monoterpenes with antichemotactic activity from Psychotria myriantha: Chemotaxonomic significance	Natural product communications			2006	1,001	0

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