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The three-dimensional genome: regulating gene expression during pluripotency and development

Mundlos, Stefan
Published in Development. 2017, vol. 144, no. 20, p. 3646-3658
Abstract The precise expression of genes in time and space during embryogenesis is largely influenced by communication between enhancers and promoters, which is propagated and governed by the physical proximity of these elements in the nucleus. Here, we review how chromatin domains organize the genome by guiding enhancers to their target genes thereby preventing non-specific interactions with other neighboring regions. We also discuss the dynamics of chromatin interactions between enhancers and promoters, as well as the consequent changes in gene expression, that occur in pluripotent cells and during development. Finally, we evaluate how genomic changes such as deletions, inversions and duplications affect 3D chromatin configuration overall and lead to ectopic enhancer-promoter contacts, and thus gene misexpression, which can contribute to abnormal development and disease.
Keywords AnimalsCRISPR-Cas SystemsCell LineageCell Nucleus/metabolismChromatin/chemistryChromatin ImmunoprecipitationEnhancer ElementsGeneticGene DeletionGene Expression RegulationDevelopmentalGenetic EngineeringGenomeGenomicsHumansMicePluripotent Stem Cells/cytologyPromoter RegionsTranscription Factors/chemistryZinc Fingers
PMID: 29042476
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Article (Published version) (5 MB) - public document Free access
Research group Contrôle épigénétique du développement embryonnaire (999)
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ANDREY, Guillaume, MUNDLOS, Stefan. The three-dimensional genome: regulating gene expression during pluripotency and development. In: Development, 2017, vol. 144, n° 20, p. 3646-3658. doi: 10.1242/dev.148304

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Deposited on : 2019-04-30

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