Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial

Gjika, Ergys; Beaulieu, Jean-Yves; Vakalopoulos, Konstantinos; Gauthier, Morgan; Bouvet, Cindy; Gonzalez, Amanda; Morello, Vanessa; Steiger, Christina; Hirsiger, Stefanie; Lipsky, Benjamin Alan; Uckay, Ilker

doi:10.1136/annrheumdis-2019-215116

Scientific article

English

Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial

ContributorsGjika, Ergys; Beaulieu, Jean-Yves

; Vakalopoulos, Konstantinos; Gauthier, Morgan; Bouvet, Cindy; Gonzalez, Amanda; Morello, Vanessa; Steiger, Christina; Hirsiger, Stefanie; Lipsky, Benjamin Alan; Uckay, Ilker

Published inAnnals of the Rheumatic Diseases

Publication date2019

Abstract

OBJECTIVE The optimal duration of postsurgical antibiotic therapy for adult native joint bacterial arthritis remains unknown. METHODS We conducted a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks of antibiotic therapy after surgical drainage of native joint bacterial arthritis in adults. Excluded were implant-related infections, episodes without surgical lavage and episodes with a follow-up of less than 2 months.

Keywords

Adverse events of antibiotics
Antibiotic duration
Native joint septic arthritis
Randomized clinical trial
Sequelae

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

GJIKA, Ergys et al. Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial. In: Annals of the Rheumatic Diseases, 2019. doi: 10.1136/annrheumdis-2019-215116