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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

ContributorsInternational Clopidogrel Pharmacogenomics Consortium
Published inAmerican Heart Journal, vol. 198, p. 152-159
Publication date2018
Abstract

The P2Y12 receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke. Platelet inhibition by clopidogrel shows wide interpatient variability, and high on-treatment platelet reactivity is a risk factor for atherothrombotic events, particularly in high-risk populations. CYP2C19 polymorphism plays an important role in this variability, but heritability estimates suggest that additional genetic variants remain unidentified. The aim of the International Clopidogrel Pharmacogenomics Consortium (ICPC) is to identify genetic determinants of clopidogrel pharmacodynamics and clinical response.

Keywords
  • Acute Coronary Syndrome/diagnosis/drug therapy/mortality
  • Aged
  • Clopidogrel/therapeutic use
  • Female
  • Genetic Association Studies
  • Genome-Wide Association Study
  • Humans
  • Internationality
  • Male
  • Middle Aged
  • Molecular Targeted Therapy/methods
  • Pharmacogenetics
  • Prognosis
  • Receptors
  • Purinergic P2Y12/drug effects/genetics
  • Risk Assessment
  • Survival Rate
  • Treatment Outcome
Citation (ISO format)
International Clopidogrel Pharmacogenomics Consortium. Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC). In: American Heart Journal, 2018, vol. 198, p. 152–159. doi: 10.1016/j.ahj.2017.12.010
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Article (Published version)
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Article (Accepted version)
accessLevelPublic
Identifiers
ISSN of the journal0002-8703
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