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Title

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

CollaborationWith : Reny, Jean-Luc / Fontana, Pierre
Published in American Heart Journal. 2018, vol. 198, p. 152-159
Abstract The P2Y12 receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke. Platelet inhibition by clopidogrel shows wide interpatient variability, and high on-treatment platelet reactivity is a risk factor for atherothrombotic events, particularly in high-risk populations. CYP2C19 polymorphism plays an important role in this variability, but heritability estimates suggest that additional genetic variants remain unidentified. The aim of the International Clopidogrel Pharmacogenomics Consortium (ICPC) is to identify genetic determinants of clopidogrel pharmacodynamics and clinical response.
Keywords Acute Coronary Syndrome/diagnosis/drug therapy/mortalityAgedClopidogrel/therapeutic useFemaleGenetic Association StudiesGenome-Wide Association StudyHumansInternationalityMaleMiddle AgedMolecular Targeted Therapy/methodsPharmacogeneticsPrognosisReceptorsPurinergic P2Y12/drug effects/geneticsRisk AssessmentSurvival RateTreatment Outcome
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PMID: 29653637
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Research group Geneva Platelet Group (13)
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INTERNATIONAL CLOPIDOGREL PHARMACOGENOMICS CONSORTIUM. Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC). In: American Heart Journal, 2018, vol. 198, p. 152-159. https://archive-ouverte.unige.ch/unige:116553

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Deposited on : 2019-04-18

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