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Scientific article
English

Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes

Published inImmunology today, vol. 16, no. 11, p. 539-546
Publication date1995
Abstract

The complex pattern of expression of major histocompatibility complex (MHC) class II molecules plays an essential role in the control of the immune response. Our understanding of the molecular mechanisms controlling this expression has benefited greatly from the identification of the regulatory factors defective in two forms of a hereditary disease of MHC class II regulation: bare lymphocyte syndrome. This has also provided new tools for the experimental modulation of MHC class II expression.

Keywords
  • Gene Expression Regulation/ immunology
  • Genes, MHC Class II/ immunology
  • Humans
  • Severe Combined Immunodeficiency/ genetics
Citation (ISO format)
REITH, Walter, STEIMLE, Viktor, MACH, Bernard. Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes. In: Immunology today, 1995, vol. 16, n° 11, p. 539–546.
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ISSN of the journal0167-5699
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