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Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction |
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Authors | ![]() | |
Published in | PloS one. 2018, vol. 13, no. 3, e0193967 | |
Abstract | A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium. | |
Keywords | Adult — Aged — Aged, 80 and over — Calcium-Binding Proteins/metabolism — Cardiomyopathy, Dilated/diagnostic imaging/metabolism/pathology/surgery — Cohort Studies — Electrocardiography — Extracellular Matrix Proteins/metabolism — Female — Heart/diagnostic imaging — Heart Transplantation — Humans — Male — Middle Aged — Multivariate Analysis — Myocardial Ischemia/diagnostic imaging/metabolism/pathology/surgery — Myocardium/metabolism/pathology — Netherlands — Switzerland — Ventricular Dysfunction, Left/diagnostic imaging/epidemiology/metabolism/pathology — Young Adult | |
Identifiers | PMID: 29529056 | |
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Research group | Groupe Pierre-Yves Martin (néphrologie) (30) | |
Project | Swiss National Science Foundation: 33CM30_140331 | |
Citation (ISO format) | WEI, Fang-Fei et al. Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction. In: PLOS ONE, 2018, vol. 13, n° 3, p. e0193967. doi: 10.1371/journal.pone.0193967 https://archive-ouverte.unige.ch/unige:115360 |