Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction

Wei, Fang-Fei; Trenson, Sander; Monney, Pierre; Yang, Wen-Yi; Pruijm, Menno; Zhang, Zhen-Yu; Bouatou, Yassine; Huang, Qi-Fang; Ponte, Belen; Martin, Pierre-Yves; Thijs, Lutgarde; Kuznetsova, Tatiana; Allegaert, Karel; Janssens, Stefan; Vermeer, Cees; Verhamme, Peter; Burnier, Michel; Bochud, Murielle; Ehret, Georg Benedikt; Staessen, Jan A

doi:10.1371/journal.pone.0193967

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Title		Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction
Authors		Wei, Fang-Fei Trenson, Sander Monney, Pierre Yang, Wen-Yi Pruijm, Menno Zhang, Zhen-Yu Bouatou, Yassine Huang, Qi-Fang Ponte, Belen Martin, Pierre-Yves Thijs, Lutgarde Kuznetsova, Tatiana Allegaert, Karel Janssens, Stefan Vermeer, Cees Verhamme, Peter Burnier, Michel Bochud, Murielle Ehret, Georg Benedikt Staessen, Jan A show all authors [1 - 20]
Published in		PLOS ONE. 2018, vol. 13, no. 3, p. e0193967
Abstract		A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium.
Keywords		Adult — Aged — Aged, 80 and over — Calcium-Binding Proteins/metabolism — Cardiomyopathy, Dilated/diagnostic imaging/metabolism/pathology/surgery — Cohort Studies — Electrocardiography — Extracellular Matrix Proteins/metabolism — Female — Heart/diagnostic imaging — Heart Transplantation — Humans — Male — Middle Aged — Multivariate Analysis — Myocardial Ischemia/diagnostic imaging/metabolism/pathology/surgery — Myocardium/metabolism/pathology — Netherlands — Switzerland — Ventricular Dysfunction, Left/diagnostic imaging/epidemiology/metabolism/pathology — Young Adult
Identifiers		DOI: 10.1371/journal.pone.0193967 PMID: 29529056
Full text		Article (Published version) (42.8 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Groupe Pierre-Yves Martin (néphrologie) (30)
Project		FNS: 33CM30-140331/1
Citation (ISO format)		WEI, Fang-Fei et al. Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction. In: PLOS ONE, 2018, vol. 13, n° 3, p. e0193967. doi: 10.1371/journal.pone.0193967 https://archive-ouverte.unige.ch/unige:115360