Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction

Wei, Fang-Fei; Trenson, Sander; Monney, Pierre; Yang, Wen-Yi; Pruijm, Menno; Zhang, Zhen-Yu; Bouatou, Yassine; Huang, Qi-Fang; Ponte, Belen; Martin, Pierre-Yves; Thijs, Lutgarde; Kuznetsova, Tatiana; Allegaert, Karel; Janssens, Stefan; Vermeer, Cees; Verhamme, Peter; Burnier, Michel; Bochud, Murielle; Ehret, Georg Benedikt; Staessen, Jan A

doi:10.1371/journal.pone.0193967

Scientific article

English

Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction

Published inPLOS ONE, vol. 13, no. 3, e0193967

Publication date2018

Abstract

A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium.

Keywords

Adult
Aged
Aged, 80 and over
Calcium-Binding Proteins/metabolism
Cardiomyopathy, Dilated/diagnostic imaging/metabolism/pathology/surgery
Cohort Studies
Electrocardiography
Extracellular Matrix Proteins/metabolism
Female
Heart/diagnostic imaging
Heart Transplantation
Humans
Male
Middle Aged
Multivariate Analysis
Myocardial Ischemia/diagnostic imaging/metabolism/pathology/surgery
Myocardium/metabolism/pathology
Netherlands
Switzerland
Ventricular Dysfunction, Left/diagnostic imaging/epidemiology/metabolism/pathology
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Groupe Pierre-Yves Martin (néphrologie) (30)

Funding

Swiss National Science Foundation - Blood pressure and renal function genetics [140331]

Citation (ISO format)

WEI, Fang-Fei et al. Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction. In: PLOS ONE, 2018, vol. 13, n° 3, p. e0193967. doi: 10.1371/journal.pone.0193967

Article (Published version)

CC BY

Identifiers

PID : unige:115360
DOI : 10.1371/journal.pone.0193967
PMID : 29529056

Journal ISSN1932-6203

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Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction

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