UNIGE document Scientific Article
previous document  unige:115360  next document
add to browser collection
Title

Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction

Authors
Wei, Fang-Fei
Trenson, Sander
Yang, Wen-Yi
Zhang, Zhen-Yu
Huang, Qi-Fang
show hidden authors show all authors [1 - 20]
Published in PLOS ONE. 2018, vol. 13, no. 3, p. e0193967
Abstract A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium.
Keywords AdultAgedAged, 80 and overCalcium-Binding Proteins/metabolismCardiomyopathy, Dilated/diagnostic imaging/metabolism/pathology/surgeryCohort StudiesElectrocardiographyExtracellular Matrix Proteins/metabolismFemaleHeart/diagnostic imagingHeart TransplantationHumansMaleMiddle AgedMultivariate AnalysisMyocardial Ischemia/diagnostic imaging/metabolism/pathology/surgeryMyocardium/metabolism/pathologyNetherlandsSwitzerlandVentricular Dysfunction, Left/diagnostic imaging/epidemiology/metabolism/pathologyYoung Adult
Identifiers
PMID: 29529056
Full text
Article (Published version) (42.8 MB) - public document Free access
Structures
Research group Groupe Pierre-Yves Martin (néphrologie) (30)
Project FNS: 33CM30-140331/1
Citation
(ISO format)
WEI, Fang-Fei et al. Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction. In: PLOS ONE, 2018, vol. 13, n° 3, p. e0193967. https://archive-ouverte.unige.ch/unige:115360

47 hits

14 downloads

Update

Deposited on : 2019-03-26

Export document
Format :
Citation style :