en
Scientific article
Open access
English

Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction

Published inPLOS ONE, vol. 13, no. 3, e0193967
Publication date2018
Abstract

A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Calcium-Binding Proteins/metabolism
  • Cardiomyopathy, Dilated/diagnostic imaging/metabolism/pathology/surgery
  • Cohort Studies
  • Electrocardiography
  • Extracellular Matrix Proteins/metabolism
  • Female
  • Heart/diagnostic imaging
  • Heart Transplantation
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Ischemia/diagnostic imaging/metabolism/pathology/surgery
  • Myocardium/metabolism/pathology
  • Netherlands
  • Switzerland
  • Ventricular Dysfunction, Left/diagnostic imaging/epidemiology/metabolism/pathology
  • Young Adult
Citation (ISO format)
WEI, Fang-Fei et al. Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction. In: PLOS ONE, 2018, vol. 13, n° 3, p. e0193967. doi: 10.1371/journal.pone.0193967
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1932-6203
387views
126downloads

Technical informations

Creation11/16/2018 8:43:00 AM
First validation11/16/2018 8:43:00 AM
Update time03/15/2023 4:02:45 PM
Status update03/15/2023 4:02:44 PM
Last indexation02/12/2024 11:39:19 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack