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Scientific article
Open access
English

Resident-memory T cells in tissue-restricted immune responses: for better or worse?

Published inFrontiers in Immunology, vol. 9, 2827
Publication date2018
Abstract

Tissue-resident-memory CD8+ T cells (TRM) have been described as a non-circulating memory T cell subset that persists at sites of previous infection. While TRM in all non-lymphoid organs probably share a core signature differentiation pathway, certain aspects of their maintenance and effector functions may vary. It is well-established that TRM provide long-lived protective immunity through immediate effector function and accelerated recruitment of circulating immune cells. Besides immune defense against pathogens, other immunological roles of TRM are less well-studied. Likewise, evidence of a putative detrimental role of TRM for inflammatory diseases is only beginning to emerge. In this review, we discuss the protective and harmful role of TRM in organ-specific immunity and immunopathology as well as prospective implications for immunomodulatory therapy.

Keywords
  • Resident memory T cells
  • Chronic
  • Inflammation
  • Infection
  • Autoimmune
Citation (ISO format)
STEINBACH, Karin, VINCENTI, Ilena, MERKLER, Doron. Resident-memory T cells in tissue-restricted immune responses: for better or worse? In: Frontiers in Immunology, 2018, vol. 9, p. 2827. doi: 10.3389/fimmu.2018.02827
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Article (Published version)
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ISSN of the journal1664-3224
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