MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells

Leibundgut-Landmann, Salomé; Waldburger, Jean-Marc; Reis e Sousa, Caetano; Acha-Orbea, Hans; Reith, Walter

doi:10.1038/ni1109

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Title		MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells
Authors		Leibundgut-Landmann, Salomé Waldburger, Jean-Marc Reis e Sousa, Caetano Acha-Orbea, Hans Reith, Walter
Published in		Nature immunology. 2004, vol. 5, no. 9, p. 899-908
Abstract		Major histocompatibility complex (MHC) class II-restricted antigen presentation is essential for the function of dendritic cells (DCs). We show here that plasmacytoid DCs (pDCs) differ from all other DC subsets with respect to expression of CIITA, the 'master regulator' of MHC class II genes. The gene encoding CIITA is controlled by three cell type-specific promoters: pI, pIII and pIV. With gene targeting in mice, we demonstrate that pDCs rely strictly on the B cell promoter pIII, whereas macrophages and all other DCs depend on pI. The molecular mechanisms driving MHC class II expression in pDCs are thus akin to those operating in lymphoid rather than myeloid cells.
Keywords		Animals — Antigen Presentation/ immunology — B-Lymphocytes/immunology — Cell Lineage — Dendritic Cells/cytology/ immunology — Flow Cytometry — Gene Targeting — Genes, MHC Class II/physiology — Histocompatibility Antigens Class II/ biosynthesis — Macrophages/immunology — Mice — Nuclear Proteins/biosynthesis/ genetics — Promoter Regions, Genetic/ physiology — Reverse Transcriptase Polymerase Chain Reaction — Trans-Activators/biosynthesis/ genetics
Identifiers		DOI: 10.1038/ni1109 PMID: 15322541
Full text		Article - Limited access to UNIGE Other version: http://www.nature.com/ni/journal/v5/n9/pdf/ni1109.pdf
Citation (ISO format)		LEIBUNDGUT-LANDMANN, Salomé et al. MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells. In: Nature immunology, 2004, vol. 5, n° 9, p. 899-908. doi: 10.1038/ni1109 https://archive-ouverte.unige.ch/unige:11417