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Nanocarrier systems and iontophoresis: complementary approaches for targeted cutaneous delivery of hydrophobic and hydrophilic drugs

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Defense Thèse de doctorat : Univ. Genève, 2018 - Sc. 5292 - 2018/12/07
Abstract A localized drug delivery provides several advantages over systemic drug delivery for treatment of dermatological diseases. Effective pharmacotherapy depends on being able to attain the right therapeutic concentrations of a drug in the target compartment within the right time-frame. This depends on the drug’s physicochemical properties, potency, pharmacokinetics, and type of formulation or delivery technique used. Development and optimization of novel formulations and delivery technique could be a good option for enhancement of drug delivery into the target compartment. This thesis work involves investigation of the targeted delivery of (i) poorly water-soluble drugs (adapalene and vismodegib) using nanocarrier systems and (ii) a hydrophilic drug (capecitabine) by using iontophoresis. Topical cutaneous delivery of therapeutic agents to treat dermatological conditions would be able to increase local drug concentrations at the disease site while reducing systemic exposure and thereby offering the potential to improve upon existing therapies.
Keywords Topical deliveryAcneAdapalenePolymeric micellesFollicular deliveryBasal cell carcinomaVismodegibBiodistributionMicroemulsionIontophoresis
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URN: urn:nbn:ch:unige-1141183
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Thesis (2.4 MB) - document accessible for UNIGE members only Limited access to UNIGE (until 2020-02-01)
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Research group Biochimie pharmaceutique
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KANDEKAR, Somnath. Nanocarrier systems and iontophoresis: complementary approaches for targeted cutaneous delivery of hydrophobic and hydrophilic drugs. Université de Genève. Thèse, 2018. https://archive-ouverte.unige.ch/unige:114118

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Deposited on : 2019-02-11

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