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Title

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Authors
Stremmel, C
Schuchert, R
Wagner, F
Thaler, R
Weinberger, T
Pick, R
Mass, E
Ishikawa-Ankerhold, H C
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Published in Nature Communications. 2018, vol. 9, no. 1, p. 75
Abstract Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.
Keywords AnimalsBlood CirculationCell LineageCell MovementCell ProliferationEmbryo, Mammalian/blood supply/cytology/embryologyEmbryonic Stem Cells/cytologyHematopoietic Stem Cells/cytologyMacrophages/cytologyMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, ConfocalTime FactorsYolk Sac/cytology/embryology
Identifiers
PMID: 29311541
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Article (Published version) (7.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Christoph Scheiermann (995)
Citation
(ISO format)
STREMMEL, C et al. Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. In: Nature Communications, 2018, vol. 9, n° 1, p. 75. https://archive-ouverte.unige.ch/unige:113704

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Deposited on : 2019-01-31

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