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Title

Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols

Authors
de-Faria, Felipe Meira
Ebrahimi, Samad Nejad
Kitano, Bruna Tiemi
Ghilardi, Amanda Franceschini
Luiz Ferreira, Anderson
de Almeida, Ana Cristina Alves
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Published in Phytochemistry. 2017, vol. 135, p. 93-105
Abstract The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.
Keywords AnimalsAnti-Inflammatory AgentsNon-Steroidal/chemistry/isolation & purification/pharmacologyAnti-Ulcer Agents/chemistry/isolation & purification/pharmacologyBignoniaceae/chemistryBrazilCytoprotectionFlavonoids/pharmacologyGlycosides/chemistry/isolation & purification/pharmacologyMalePlant Leaves/chemistryPlant Roots/chemistryPlantsMedicinal/chemistryPolyphenols/chemistry/isolation & purification/pharmacologyRatsRatsWistarStomach Ulcer/drug therapy
Identifiers
PMID: 28010885
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Article (Published version) (1.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Phytochimie et produits naturels bioactifs
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(ISO format)
QUINTINO DA ROCHA, Claudia et al. Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols. In: Phytochemistry, 2017, vol. 135, p. 93-105. doi: 10.1016/j.phytochem.2016.12.002 https://archive-ouverte.unige.ch/unige:112385

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Deposited on : 2018-12-18

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