Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols

Article Article scientifique Article Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols eng 2017 author Quintino Da Rocha Claudia 758805 author de-Faria Felipe Meira author Marcourt Laurence 729234 author Ebrahimi Samad Nejad author Kitano Bruna Tiemi author Ghilardi Amanda Franceschini author Luiz Ferreira Anderson author de Almeida Ana Cristina Alves author Dunder Ricardo José author Souza-Brito Alba Regina Monteiro author Hamburger Matthias author Vilegas Wagner author Queiroz Emerson Ferreira author Wolfender Jean-Luc 135649 93-105 10.1016/j.phytochem.2016.12.002 28010885 0031-9422 The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy. Animals Anti-Inflammatory Agents Non-Steroidal/chemistry/isolation & purification/pharmacology Anti-Ulcer Agents/chemistry/isolation & purification/pharmacology Bignoniaceae/chemistry Brazil Cytoprotection Flavonoids/pharmacology Glycosides/chemistry/isolation & purification/pharmacology Male Plant Leaves/chemistry Plant Roots/chemistry Plants Medicinal/chemistry Polyphenols/chemistry/isolation & purification/pharmacology Rats Rats Wistar Stomach Ulcer/drug therapy Dewey 615 31 Section des sciences pharmaceutiques 17 false 882 Phytochimie et produits naturels bioactifs Phytochemistry 135 e3741890-4de0-48b8-ac95-c9503ed0e4a0 Article (Published version) Restricted 28010885.pdf 1517569 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols	Phytochemistry			2017	386	1

Archive ouverte UNIGE

Quintino Da Rocha, Claudia