Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance

Article Article scientifique Article Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance eng 2018 author Choong Eva 649281 author Uppugunduri Chakradhara Rao Satyanarayana author Marino Denis 649455 author Kuntzinger Mélanie 594442 author Doffey-Lazeyras Fabienne 120473 author Lo Piccolo Rodolfo 524807 author Chalandon Yves 644957 author Peters Christina author Daali Youssef 46042 author Ansari Djaberi Marc Georges 61572 84-92 10.1097/FTD.0000000000000468 29189665 0163-4356 Busulfan (Bu) is an alkylating agent used as part of the conditioning regimen in pediatric patients before hematopoietic stem cell transplantation. Despite intravenous (IV) administration and dosing recommendations based on age and weight, reports have revealed interindividual variability in Bu pharmacokinetics and the outcomes of hematopoietic stem cell transplantation. In this context, adjusting doses to Bu's narrow therapeutic window is advised. We aimed to assess the utility of therapeutic drug monitoring (TDM) of Bu in children, the reliability of Bu quantification methods, and its stability in plasma when stored for up to 5 years. Alkylating Agents/blood/pharmacokinetics Busulfan/blood/pharmacokinetics Child Chromatography, High Pressure Liquid/methods Dose-Response Relationship, Drug Drug Monitoring/methods Drug Stability Hematopoietic Stem Cell Transplantation/methods Humans Quality Control Reproducibility of Results Tandem Mass Spectrometry/methods Time Factors Dewey 616 Dewey 617 Dewey 618 56 Département de médecine 221 58 Département de pédiatrie, gynécologie et obstétrique 223 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 302 Groupe Desmeules Jules (pharmacologie/toxicologie) 567 1216 Leucémie et transplantation allogénique de cellules souches hématopoïétiques 982 564 Oncologie et hématologie pédiatrique 907 1280 Pharmaco-omiques et médecine de précision 1003 Therapeutic Drug Monitoring 40 1 c4a9500e-0ca7-4545-9efe-093fae2dd3e6 Article (Published version) Public 00007691-201802000-00009.pdf 579476 application/pdf CC BY openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance	Therapeutic Drug Monitoring			2018	772	379

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Kuntzinger, Mélanie