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Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study

Published inJournal of Endocrinological Investigation, vol. 41, no. 7, p. 799-808
Publication date2018
Abstract

Arginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether apparent 11β-HSD2 activity, estimated using urinary cortisol-to-cortisone ratio, modulates the association between plasma copeptin, as AVP surrogate, and insulin resistance/MetS in the general adult population.

Keywords
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2/metabolism
  • Adult
  • Age Factors
  • Aged
  • 80 and over
  • Aging/blood/metabolism
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Type 2/complications/metabolism
  • Female
  • Glycopeptides/blood
  • Humans
  • Insulin Resistance/physiology
  • Male
  • Metabolic Syndrome/metabolism
  • Middle Aged
  • Young Adult
Citation (ISO format)
CANIVELL, S et al. Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study. In: Journal of Endocrinological Investigation, 2018, vol. 41, n° 7, p. 799–808. doi: 10.1007/s40618-017-0807-7
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0391-4097
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306downloads

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Creation11/16/2018 9:04:00 AM
First validation11/16/2018 9:04:00 AM
Update time03/15/2023 3:07:29 PM
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