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Title

Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study

Authors
Canivell, S
Mohaupt, M
Ackermann, D
Escher, G
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Published in Journal of Endocrinological Investigation. 2018, vol. 41, no. 7, p. 799-808
Abstract Arginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether apparent 11β-HSD2 activity, estimated using urinary cortisol-to-cortisone ratio, modulates the association between plasma copeptin, as AVP surrogate, and insulin resistance/MetS in the general adult population.
Keywords 11-beta-Hydroxysteroid Dehydrogenase Type 2/metabolismAdultAge FactorsAged80 and overAging/blood/metabolismCross-Sectional StudiesDiabetes MellitusType 2/complications/metabolismFemaleGlycopeptides/bloodHumansInsulin Resistance/physiologyMaleMetabolic Syndrome/metabolismMiddle AgedYoung Adult
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PMID: 29235050
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Research group Hypertension artérielle (128)
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CANIVELL, S et al. Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study. In: Journal of Endocrinological Investigation, 2018, vol. 41, n° 7, p. 799-808. doi: 10.1007/s40618-017-0807-7 https://archive-ouverte.unige.ch/unige:111687

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Deposited on : 2018-11-30

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