UNIGE document Scientific Article
previous document  unige:111208  next document
add to browser collection
Title

VTA DA neuron excitatory synapses in Shank3 Δex4-9 mouse line

Authors
Published in Synapse. 2017, vol. 71, no. 6
Abstract Several mutations within SHANK3 gene have been identified in Autism Spectrum Disorder patients and several studies have now started to show that those mutations could impact different brain circuits leading to the heterogeneity of the disease. Here we show that, compared to a mouse model lacking SHANK3 proline-rich containing isoforms, in a mouse model lacking SHANK3 ANK(yrin)-domain containing isoforms, the excitatory synaptic transmission within the Ventral Tegmental Area is not affected. We discuss about the possibility that different domains of SHANK3 are involved in regulating the synapses in a circuit-specific manner resulting in different behavioral and synaptic phenotypes.
Keywords AnimalsAutism Spectrum Disorder/genetics/physiopathologyDopaminergic Neurons/metabolism/physiologyExcitatory Postsynaptic PotentialsGene DeletionMiceNerve Tissue Proteins/chemistry/genetics/metabolismPhenotypeProtein DomainsProtein Isoforms/chemistry/genetics/metabolismReceptorsAMPA/chemistry/genetics/metabolismReceptorsN-Methyl-D-Aspartate/chemistry/genetics/metabolismVentral Tegmental Area/cytology/metabolism/physiology
Identifiers
PMID: 28002633
Full text
Article (Published version) (573 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Les dysfonctions synaptiques du cerveau (971)
Citation
(ISO format)
BARISELLI, Sebastiano, BELLONE, Camilla. VTA DA neuron excitatory synapses in Shank3 Δex4-9 mouse line. In: Synapse, 2017, vol. 71, n° 6. doi: 10.1002/syn.21955 https://archive-ouverte.unige.ch/unige:111208

201 hits

5 downloads

Update

Deposited on : 2018-11-21

Export document
Format :
Citation style :