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Scientific article
English

The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation

Contributors

Suter, Tobias; Biollaz, Gregoire; Gatto, Dominique; Bernasconi, Luca; Herren, Tobias; Reith, Walter; Fontana, Adriano

Published in

European Journal of Immunology, vol. 33, no. 11, p. 2998-3006

Publication date

2003

Abstract

Dendritic cells (DC) are unique in their ability to prime naive T cells and initiate adaptive immunity. In recent years, DC were identified in the inflamed central nervous system (CNS), but their role in the initiation or regulation of the tissue specific immune response is unknown. As shown here, DC isolated from mice with experimental autoimmune encephalomyelitis (EAE) exhibit a maturational phenotype similar to immature bone marrow-derived DC or splenic DC as characterized by intermediate surface MHC class II and low expression of the costimulatory molecule CD80. However, they are unable to prime naive T cells. Moreover, they inhibit T cell proliferation stimulated by mature bone marrow-derived DC. TGFbeta, IL-10 and TRAIL were found to significantly contribute to the CNS-DC-mediated inhibition of allo-T cell proliferation. Thus CNS-DC may be the key responsibles for maintaining immune privilege within the inflamed CNS.

Keywords

  • Animals
  • Antigens, CD80/metabolism
  • Autoimmune Diseases of the Nervous System/metabolism
  • Brain/ immunology/metabolism
  • Dendritic Cells/ immunology
  • Histocompatibility Antigens Class II/metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • T-Lymphocytes/ immunology

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

SUTER, Tobias et al. The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation. In: European Journal of Immunology, 2003, vol. 33, n° 11, p. 2998–3006. doi: 10.1002/eji.200323611

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Article

Identifiers

Journal ISSN

0014-2980
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Technical informations

Creation

27/08/2010 13:33:38

First validation

27/08/2010 13:33:38

Update

14/03/2023 16:02:20

Status update

14/03/2023 16:02:19

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