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Title

GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells"

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Published in Cell Calcium. 2018, vol. 73, p. 70-71
Abstract GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca2+ entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS.
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PMID: 29684786
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Article (Published version) (159 Kb) - public document Free access
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Research group Signaux intracellulaires (210)
Project FNS: 31003A_169491
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NUNES-HASLER, Paula, DEMAUREX, Nicolas. GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". In: Cell Calcium, 2018, vol. 73, p. 70-71. https://archive-ouverte.unige.ch/unige:109621

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Deposited on : 2018-10-23

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