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GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells"

Published inCell Calcium, vol. 73, p. 70-71
Publication date2018
Abstract

GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca2+ entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS.

Citation (ISO format)
NUNES-HASLER, Paula, DEMAUREX, Nicolas. GRAM marks the spot for STIM. Commentary on ‘GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells’. In: Cell Calcium, 2018, vol. 73, p. 70–71. doi: 10.1016/j.ceca.2018.04.002
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ISSN of the journal0143-4160
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Creation08/31/2018 3:41:00 PM
First validation08/31/2018 3:41:00 PM
Update time03/15/2023 8:49:36 AM
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