GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells"

Nunes-Hasler, Paula; Demaurex, Nicolas

doi:10.1016/j.ceca.2018.04.002

Scientific article

Comment

English

GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells"

ContributorsNunes-Hasler, Paula

; Demaurex, Nicolas

Published inCell Calcium, vol. 73, p. 70-71

Publication date2018

Abstract

GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca2+ entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Research groups

Funding

Swiss National Science Foundation - Calcium signaling at membrane contact sites during phagocytosis [31003A_169491]

Citation (ISO format)

NUNES-HASLER, Paula, DEMAUREX, Nicolas. GRAM marks the spot for STIM. Commentary on ‘GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells’. In: Cell Calcium, 2018, vol. 73, p. 70–71. doi: 10.1016/j.ceca.2018.04.002

Article (Published version)

CC0

Identifiers

PID : unige:109621
DOI : 10.1016/j.ceca.2018.04.002
PMID : 29684786

ISSN of the journal0143-4160

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Creation31/08/2018 15:41:00

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GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells"

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