Scientific article
Open access

Behavioral variant frontotemporal dementia patients do not succumb to the Allais paradox

Published inFrontiers in Neuroscience, vol. 8
Publication date2014

The Allais Paradox represents one of the earliest empirical challenges to normative models of decision-making, and suggests that choices in one part of a gamble may depend on the possible outcome in another, independent, part of the gamble—a violation of the so-called “independence axiom.” To account for Allaisian behavior, one well-known class of models propose that individuals' choices are influenced not only by possible outcomes resulting from one's choices, but also the anticipation of regret for foregone options. Here we test the regret hypothesis using a population of patients with behavioral variant frontotemporal dementia (bvFTD), a clinical population known to present ventromedial prefrontal cortex dysfunctions and associated with impaired regret processing in previous studies of decision-making. Compared to matched controls and Alzheimer's disease (AD) patients, we found a striking diminution of Allaisian behavior among bvFTD patients. These results are consistent with the regret hypothesis and furthermore suggest a crucial role for prefrontal regions in choices that typically stands in contradiction with a basic axiom of rational decision-making.

  • Allais paradox
  • Anticipated regret
  • Emotions
  • Rationality
  • Frontotemporal dementia
Citation (ISO format)
BERTOUX, Maxime et al. Behavioral variant frontotemporal dementia patients do not succumb to the Allais paradox. In: Frontiers in Neuroscience, 2014, vol. 8. doi: 10.3389/fnins.2014.00287
Main files (1)
Article (Published version)
ISSN of the journal1662-453X

Technical informations

Creation10/18/2018 10:50:00 AM
First validation10/18/2018 10:50:00 AM
Update time03/15/2023 8:48:32 AM
Status update03/15/2023 8:48:31 AM
Last indexation02/12/2024 12:55:35 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack