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Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile

Published in The journal of antimicrobial chemotherapy. 2008, vol. 62, no. 3, p. 601-607
Abstract OBJECTIVES: The aim of this study was to determine the temporal relation between the use of antibiotics and alcohol-based hand rubs (ABHRs) and the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile. METHODS: An interventional time-series analysis was performed to evaluate the impact of two promotion campaigns on the consumption of ABHRs and to assess their effect on the incidence of non-duplicate clinical isolates of MRSA and C. difficile from February 2000 through September 2006. This analysis was combined with a transfer function model of aggregated data on antibiotic use. RESULTS: Consumption of ABHRs correlated with MRSA, but not with C. difficile. The final model demonstrated the immediate effect of the second hand hygiene promotion campaign and an additional temporal effect of fluoroquinolone (time lag, 1 month; i.e. antibiotic effect delayed for 1 month), macrolide (lag 1 and 4 months), broad-spectrum cephalosporins (lag 3, 4 and 5 months) and piperacillin/tazobactam (lag 3 months) use. The final model explained 57% of the MRSA variance over time. In contrast, the model for C. difficile showed only an effect for broad-spectrum cephalosporins (lag 1 month). CONCLUSIONS: We observed an aggregate-level relation between the monthly MRSA incidence and the use of different antibiotic classes and increased consumption of ABHR after a successful hand hygiene campaign, while no association with ABHR use was detected for C. difficile.
Keywords Academic Medical CentersAlcohols/administration & dosageAnti-Bacterial Agents/therapeutic useClostridium difficile/isolation & purificationDisinfectants/administration & dosageDrug Utilization/statistics & numerical dataEnterocolitis, Pseudomembranous/epidemiology/microbiologyHandwashing/methodsHealth PersonnelHumansIncidenceMethicillin ResistanceStaphylococcal Infections/epidemiology/microbiologyStaphylococcus aureus/drug effects/isolation & purification
PMID: 18468995
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Research groups Analyse génomique et fonctionnelle du staphylocoque doré (604)
Epidémiologie et contrôle de la résistance aux antibiotiques (866)
Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)
(ISO format)
VERNAZ, Nathalie et al. Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile. In: The journal of antimicrobial chemotherapy, 2008, vol. 62, n° 3, p. 601-607. doi: 10.1093/jac/dkn199 https://archive-ouverte.unige.ch/unige:1093

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Deposited on : 2009-03-06

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