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Proceedings chapter
English

A preliminary study on the prediction of human protein functions

PublisherHeidelberg : Springer
Collection
  • Lecture Notes in Computer Science; 6686
Publication date2011
Abstract

In the human proteome, about 5'000 proteins lack experimentally validated functional information. In this work we propose to tackle the problem of human protein function prediction by three distinct supervised learning schemes: one-versus-all classification; tournament learning; multi-label learning. Target values of supervised learning models are represented by the nodes of a subset of the Gene Ontology, which is widely used as a benchmark for functional prediction. With an independent dataset including very difficult cases the recall measure reached a reasonable performance for the first 50 ranked predictions, on average; however, average precision was quite low.

Research group
Citation (ISO format)
BOLOGNA, Guido et al. A preliminary study on the prediction of human protein functions. In: Foundations on Natural and Artificial Computation: 4th International Work-conference on the Interplay Between Natural and Artificial Computation, IWINAC 2011. Heidelberg : Springer, 2011. p. 334–343. (Lecture Notes in Computer Science)
Main files (1)
Proceedings chapter (Published version)
accessLevelRestricted
Identifiers
  • PID : unige:108944
ISBN978-3-642-21343-4
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First validation09/15/2018 1:38:00 PM
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