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Scientific article
English

Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population

Published inArteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 12, p. 2342-2349
Publication date2017
Abstract

We aimed to determine whether autoantibodies against apoA-1 (apolipoprotein A-1; anti-apoA-1 IgG) predict incident coronary artery disease (CAD), defined as adjudicated incident myocardial infarction, angina, percutaneous coronary revascularization, or bypass grafting, in the general population. We further investigated whether this association is modulated by a functional CD14 receptor single nucleotide polymorphism.

Keywords
  • Adult
  • Apolipoprotein A-I/immunology
  • Autoantibodies/blood
  • Biomarkers/blood
  • Chi-Square Distribution
  • Coronary Artery Disease/blood/epidemiology/genetics/immunology
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Heterozygote
  • Homozygote
  • Humans
  • Immunoglobulin G/blood
  • Incidence
  • Kaplan-Meier Estimate
  • Lipopolysaccharide Receptors/genetics/immunology
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Switzerland/epidemiology
  • Time Factors
Citation (ISO format)
ANTIOCHOS, Panagiotis et al. Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2017, vol. 37, n° 12, p. 2342–2349. doi: 10.1161/ATVBAHA.117.309602
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Article (Published version)
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Identifiers
ISSN of the journal1079-5642
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