Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population

Antiochos, Panagiotis; Marques-Vidal, Pedro; Virzi, Julien; Pagano, Sabrina; Satta Poschung, Nathalie; Hartley, Oliver; Montecucco, Fabrizio; Mach, François; Kutalik, Zoltan; Waeber, Gerard; Vollenweider, Peter; Vuilleumier, Nicolas

doi:10.1161/ATVBAHA.117.309602

Scientific article

English

Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population

ContributorsAntiochos, Panagiotis; Marques-Vidal, Pedro; Virzi, Julien; Pagano, Sabrina

; Satta Poschung, Nathalie; Hartley, Oliver

; Montecucco, Fabrizio; Mach, François; Kutalik, Zoltan; Waeber, Gerard; Vollenweider, Peter; Vuilleumier, Nicolas

Published inArteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 12, p. 2342-2349

Publication date2017

Abstract

We aimed to determine whether autoantibodies against apoA-1 (apolipoprotein A-1; anti-apoA-1 IgG) predict incident coronary artery disease (CAD), defined as adjudicated incident myocardial infarction, angina, percutaneous coronary revascularization, or bypass grafting, in the general population. We further investigated whether this association is modulated by a functional CD14 receptor single nucleotide polymorphism.

Keywords

Adult
Apolipoprotein A-I/immunology
Autoantibodies/blood
Biomarkers/blood
Chi-Square Distribution
Coronary Artery Disease/blood/epidemiology/genetics/immunology
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Heterozygote
Homozygote
Humans
Immunoglobulin G/blood
Incidence
Kaplan-Meier Estimate
Lipopolysaccharide Receptors/genetics/immunology
Male
Middle Aged
Multivariate Analysis
Phenotype
Polymorphism, Single Nucleotide
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Switzerland/epidemiology
Time Factors

Affiliation entities

Research groups

Citation (ISO format)

ANTIOCHOS, Panagiotis et al. Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2017, vol. 37, n° 12, p. 2342–2349. doi: 10.1161/ATVBAHA.117.309602

Article (Published version)

Identifiers

PID : unige:108546
DOI : 10.1161/ATVBAHA.117.309602
PMID : 29074586

Journal ISSN1079-5642

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Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population

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