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Title

Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population

Authors
Antiochos, Panagiotis
Marques-Vidal, Pedro
Satta, Nathalie
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Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2017, vol. 37, no. 12, p. 2342-2349
Abstract We aimed to determine whether autoantibodies against apoA-1 (apolipoprotein A-1; anti-apoA-1 IgG) predict incident coronary artery disease (CAD), defined as adjudicated incident myocardial infarction, angina, percutaneous coronary revascularization, or bypass grafting, in the general population. We further investigated whether this association is modulated by a functional CD14 receptor single nucleotide polymorphism.
Keywords AdultApolipoprotein A-I/immunologyAutoantibodies/bloodBiomarkers/bloodChi-Square DistributionCoronary Artery Disease/blood/epidemiology/genetics/immunologyFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHeterozygoteHomozygoteHumansImmunoglobulin G/bloodIncidenceKaplan-Meier EstimateLipopolysaccharide Receptors/genetics/immunologyMaleMiddle AgedMultivariate AnalysisPhenotypePolymorphism, Single NucleotideProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSwitzerland/epidemiologyTime Factors
Identifiers
PMID: 29074586
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Structures
Research groups Chimie et protéomique clinique (270)
Hiv (835)
Traits génétiques complexes (901)
L'athérosclérose et ses complications cliniques (591)
Citation
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ANTIOCHOS, Panagiotis et al. Impact of CD14 Polymorphisms on Anti-Apolipoprotein A-1 IgG-Related Coronary Artery Disease Prediction in the General Population. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2017, vol. 37, n° 12, p. 2342-2349. doi: 10.1161/ATVBAHA.117.309602 https://archive-ouverte.unige.ch/unige:108546

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Deposited on : 2018-09-26

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