Immigrants face numerous obstacles to integrate themselves into the Swiss labor market. One issue is the skills underutilization, which results in a brain waste. This study examines the determinants of de-qualification and de-emancipation among the recently arrived high-skilled immigrant population in Switzerland with a gender-oriented perspective. Using data from the Migration-Mobility Survey carried out in 2016 by the nccr – on the move, statistical analyses are conducted with binomial logistic regression models. Results indicate that women have significantly higher probabilities of being overeducated, overqualified, homemaker but not educated unemployed compared to men. Furthermore, family reunification as reason to migrate, the number of children as well as the region of origin are important variables to explain the (un-)successful professional integration of recently arrived immigrants. The addition of disadvantages increases the probability of being in a skills underexploitation situation and perpetuates intersectional inequality in the Swiss labor market driven by immigrant status, origin and gender. There is an urgent need to rethink the society and to remove the stereotypes in order to enhance the situation of discriminated populations.